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Volume 24
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Review

The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates

by
Mariette Hanot
,
Ludivine Raby
,
Pamela Völkel
,
Xuefen Le Bourhis
and
Pierre-Olivier Angrand
*
Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277–CANTHER–Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(3), 2322; https://doi.org/10.3390/ijms24032322
Submission received: 29 December 2022 / Revised: 20 January 2023 / Accepted: 21 January 2023 / Published: 24 January 2023
(This article belongs to the Special Issue Advances in Animal Models in Biomedical Research)
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Abstract

Polycomb group (PcG) proteins are highly conserved proteins assembled into two major types of complexes, PRC1 and PRC2, involved in the epigenetic silencing of a wide range of gene expression programs regulating cell fate and tissue development. The crucial role of PRC1 and PRC2 in the fundamental cellular processes and their involvement in human pathologies such as cancer attracted intense attention over the last few decades. Here, we review recent advancements regarding PRC1 and PRC2 function using the zebrafish model. We point out that the unique characteristics of the zebrafish model provide an exceptional opportunity to increase our knowledge of the role of the PRC1 and PRC2 complexes in tissue development, in the maintenance of organ integrity and in pathology.
Keywords: zebrafish; epigenetics; PRC1; PRC2; morpholino; gene editing zebrafish; epigenetics; PRC1; PRC2; morpholino; gene editing

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MDPI and ACS Style

Hanot, M.; Raby, L.; Völkel, P.; Le Bourhis, X.; Angrand, P.-O. The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates. Int. J. Mol. Sci. 2023, 24, 2322. https://doi.org/10.3390/ijms24032322

AMA Style

Hanot M, Raby L, Völkel P, Le Bourhis X, Angrand P-O. The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates. International Journal of Molecular Sciences. 2023; 24(3):2322. https://doi.org/10.3390/ijms24032322

Chicago/Turabian Style

Hanot, Mariette, Ludivine Raby, Pamela Völkel, Xuefen Le Bourhis, and Pierre-Olivier Angrand. 2023. "The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates" International Journal of Molecular Sciences 24, no. 3: 2322. https://doi.org/10.3390/ijms24032322

APA Style

Hanot, M., Raby, L., Völkel, P., Le Bourhis, X., & Angrand, P.-O. (2023). The Contribution of the Zebrafish Model to the Understanding of Polycomb Repression in Vertebrates. International Journal of Molecular Sciences, 24(3), 2322. https://doi.org/10.3390/ijms24032322

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