Dalbavancin Boosts the Ability of Neutrophils to Fight Methicillin-Resistant Staphylococcus aureus
Abstract
:1. Introduction
2. Results
2.1. Effect of Dalbavancin at Different Concentrations on Neutrophil Intracellular MRSA Killing Activity
2.2. Effect of Dalbavancin on Neutrophil Viability
2.3. Effect of Dalbavancin on ROS Production by Neutrophils
2.4. Effect of Dalbavancin on NETosis and Degranulation
2.5. Cytokine Release Pattern of Dalbavancin Pre-Treated PMNs upon MRSA or PMA Stimulation
3. Discussion
4. Materials and Methods
4.1. Intracellular Killing Assay
4.2. Phenotypic Analysis of PMN Apoptosis
4.3. Oxidative Burst Assay
4.4. Degranulation
4.5. NET-Forming Capacity Assay
4.6. Cytokine Release
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Scutera, S.; Sparti, R.; Comini, S.; Menotti, F.; Musso, T.; Cuffini, A.M.; Allizond, V.; Banche, G. Dalbavancin Boosts the Ability of Neutrophils to Fight Methicillin-Resistant Staphylococcus aureus. Int. J. Mol. Sci. 2023, 24, 2541. https://doi.org/10.3390/ijms24032541
Scutera S, Sparti R, Comini S, Menotti F, Musso T, Cuffini AM, Allizond V, Banche G. Dalbavancin Boosts the Ability of Neutrophils to Fight Methicillin-Resistant Staphylococcus aureus. International Journal of Molecular Sciences. 2023; 24(3):2541. https://doi.org/10.3390/ijms24032541
Chicago/Turabian StyleScutera, Sara, Rosaria Sparti, Sara Comini, Francesca Menotti, Tiziana Musso, Anna Maria Cuffini, Valeria Allizond, and Giuliana Banche. 2023. "Dalbavancin Boosts the Ability of Neutrophils to Fight Methicillin-Resistant Staphylococcus aureus" International Journal of Molecular Sciences 24, no. 3: 2541. https://doi.org/10.3390/ijms24032541