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Volume 24
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Review

From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies

by
Irina Alekseenko
1,2,
Liya Kondratyeva
1,2,
Igor Chernov
1 and
Eugene Sverdlov
2,*
1
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia
2
National Research Center “Kurchatov Institute”, 123182 Moscow, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(3), 2796; https://doi.org/10.3390/ijms24032796
Submission received: 30 November 2022 / Revised: 22 January 2023 / Accepted: 23 January 2023 / Published: 1 February 2023
(This article belongs to the Special Issue Latest Review Papers in Molecular Oncology 2023)
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Abstract

The unprecedented non-reproducibility of the results published in the field of cancer research has recently come under the spotlight. In this short review, we try to highlight some general principles in the organization and evolution of cancerous tumors, which objectively lead to their enormous variability and, consequently, the irreproducibility of the results of their investigation. This heterogeneity is also extremely unfavorable for the effective use of molecularly targeted medicine. Against the seemingly comprehensive background of this heterogeneity, we single out two supramolecular characteristics common to all tumors: the clustered nature of tumor interactions with their microenvironment and the formation of biomolecular condensates with tumor-specific distinctive features. We suggest that these features can form the basis of strategies for tumor-specific supramolecular targeted therapies.
Keywords: cancer; cell–cell interaction; synapses; biomolecular condensate; microenvironment; tumor heterogeneity cancer; cell–cell interaction; synapses; biomolecular condensate; microenvironment; tumor heterogeneity

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MDPI and ACS Style

Alekseenko, I.; Kondratyeva, L.; Chernov, I.; Sverdlov, E. From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies. Int. J. Mol. Sci. 2023, 24, 2796. https://doi.org/10.3390/ijms24032796

AMA Style

Alekseenko I, Kondratyeva L, Chernov I, Sverdlov E. From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies. International Journal of Molecular Sciences. 2023; 24(3):2796. https://doi.org/10.3390/ijms24032796

Chicago/Turabian Style

Alekseenko, Irina, Liya Kondratyeva, Igor Chernov, and Eugene Sverdlov. 2023. "From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies" International Journal of Molecular Sciences 24, no. 3: 2796. https://doi.org/10.3390/ijms24032796

APA Style

Alekseenko, I., Kondratyeva, L., Chernov, I., & Sverdlov, E. (2023). From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies. International Journal of Molecular Sciences, 24(3), 2796. https://doi.org/10.3390/ijms24032796

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