Next Article in Journal
Bioactive and Physico-Chemical Assessment of Innovative Poly(lactic acid)-Based Biocomposites Containing Sage, Coconut Oil, and Modified Nanoclay
Previous Article in Journal
Increased Density of Endogenous Adenosine A2A Receptors in Atrial Fibrillation: From Cellular and Porcine Models to Human Patients
Previous Article in Special Issue
The Soluble Guanylate Cyclase Stimulator BAY 41-2272 Attenuates Transforming Growth Factor β1-Induced Myofibroblast Differentiation of Human Corneal Keratocytes
 
 
Article
Peer-Review Record

Tri-Lineage Differentiation Potential of Osteosarcoma Cell Lines and Human Bone Marrow Stromal Cells from Different Anatomical Locations

Int. J. Mol. Sci. 2023, 24(4), 3667; https://doi.org/10.3390/ijms24043667
by Hannah L. Smith 1,2, Juliet C. Gray 1, Stephen A. Beers 1 and Janos M. Kanczler 2,*
Reviewer 1:
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(4), 3667; https://doi.org/10.3390/ijms24043667
Submission received: 18 January 2023 / Accepted: 9 February 2023 / Published: 11 February 2023
(This article belongs to the Special Issue Molecular Morphology and Function of Stromal Cells 2.0)

Round 1

Reviewer 1 Report

Reviewers’ comments for the Manuscript ID: ijms-2199323

The manuscript title:Tri-lineage differentiation potential of osteosarcoma cell lines and human bone marrow stromal cells from different anatomical locations”.

In the current manuscript, authors isolated the Primary human bone marrow stromal cells (HBMSCs) from the femoral epiphysis (FE) and femoral metaphysis/diaphysis (FD) of patients undergoing hip replacement surgery and characterized them for tri-lineage differentiation, such as osteogenic, adipogenic and chondrogenic differentiation and compared with two osteosarcoma cell lines, Saos-2 and MG63. The results clearly, demonstrate that FD-derived HBMSCs is closely related SaOS2 cell line in all tri-lineage differentiation (osteogenic, adipogenic and chondrogenic). It is well written and organized manuscripts. All the results are clearly presented, so the manuscript is recommending to publication in International Journal of Molecular Sciences in its current form.

Reviewer 2 Report

In this manuscript, the authors report differentiation potential of bone marrow stromal cells derived from different anatomical locations in human. The study is designed and executed well and the conclusions are supported by adequate data. The manuscript may be considered for publication.

Back to TopTop