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Volume 24
Issue 4
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Review
Peer-Review Record

The Emerging Role of N-Methyl-D-Aspartate (NMDA) Receptors in the Cardiovascular System: Physiological Implications, Pathological Consequences, and Therapeutic Perspectives

Int. J. Mol. Sci. 2023, 24(4), 3914; https://doi.org/10.3390/ijms24043914
by Teresa Soda 1, Valentina Brunetti 2, Roberto Berra-Romani 3 and Francesco Moccia 2,*
Reviewer 1: Anonymous
Reviewer 2:
Elena Varlamova
Int. J. Mol. Sci. 2023, 24(4), 3914; https://doi.org/10.3390/ijms24043914
Submission received: 27 January 2023 / Revised: 9 February 2023 / Accepted: 13 February 2023 / Published: 15 February 2023
(This article belongs to the Special Issue Calcium Signaling in Mammalian Cells: From Physiology to Pathology)

Round 1

Reviewer 1 Report

The authors should be praised for this review, as it is very extensive and well-constructed. I started reading and could not stop until I finished. Actually, I learned quite a lot by reading this manuscript. Frankly, I hope it is published soon as I would love to use the  figure in the review on the flux-independent mode in teaching physiology. This concept is not yet presented in general physiology textbooks.

Two topics came to mind while reading through the manuscript that the authors may wish to address.

1.    Line 190: “However, these pro-arrhythmic effects were reversed by MK-801 [41].”
MK-801---- is this not a broad Ca2+ channel blocker and can even block pre-synaptic voltage-gated Ca2+ channels?

2.    The widely read book and even a NETFLIX movie “Brain on Fire” is about the autoimmune disorder where one develops that antibody to the NMDA receptor. I am not sure if it is to a particular subunit or to a complex. It could be interesting to note if or suggest that data be examined if these individuals also suffer from cardiovascular issues due to the possibility of the NMDA in the vascular also being targeted.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

1) glutamate-gated ionotropic receptors. This is not true. The correct definition is ligand-gated ion channels that are activated by the neurotransmitter glutamate.

2) A figure showing the role of calcium ions and mitochondrial overload with NMDAR activation should be presented. Those. figure 2 should at least reflect the role of calcium in pathologies. I would recommend making a separate chapter in the article devoted to these effects.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

The article can be accepted for publication in its current form

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