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Volume 24
Issue 4
10.3390/ijms24044148
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Review
Peer-Review Record

Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis

Int. J. Mol. Sci. 2023, 24(4), 4148; https://doi.org/10.3390/ijms24044148
by Finn E. von Eyben 1,*, Karsten Kristiansen 2,3,4, Daniel S. Kapp 5, Rong Hu 6, Ovidiu Preda 7 and Francisco F. Nogales 8
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(4), 4148; https://doi.org/10.3390/ijms24044148
Submission received: 19 December 2022 / Revised: 15 February 2023 / Accepted: 15 February 2023 / Published: 19 February 2023
(This article belongs to the Special Issue New Evidence and Emerging Strategies in the Management of Testicular Cancer In Vivo and In Vitro)

Round 1

Reviewer 1 Report

The authors reviwed the role of some epigenetic genes in chromosome-12 in testi-tumorigenesis.  The review is well-written and may gain so many interest. However, I have minor suggestions:

-No statistical significance have been mentioned in the review. The study or the referred study must have statistical information (e.g. P-value) of the regulations. I hope that authors provide a table of those stats.

-so many double spaces between words.

-expression of the gene. . => remove one dot

Author Response

Thank you for good suggestions We changed according to the suggestions: For Abstract: We added a sentence for aim and methodology. For p values we added a few p values. For too long interspace between words, we show elimination of the double space. In our reply, we refer to the page and lines in the the IJMS 2140089 version 1 as requested by the editor. See attached our minor changes:

Reviewer 2 Report

The manuscript entitled (Epigenetic Regulation of Driver Genes in Testicular Tumorigenesis) submitted by Eyben et al. presents a review of epigenetic regulation of the driver genes as an important factor for TGCT and for oncology. The introduction and discussion sections are well-presented. References are updated and figures are provided in high resolution and in an informative way. The review can be accepted after minor revisions that may include:

1. The abstract should be modified. The authors should state what they focus on in their review and how they collect their data in brief. (since it is a review article).

Author Response

Thank you for good suggestions We changed according to the suggestions: For Abstract: We added a sentence for aim and methodology. For p values we added a few p values. For too long interspace between words, we show elimination of the double space. In our reply, we refer to the page and lines in the the IJMS 2140089 version 1 as requested by the editor. See attached our minor changes:
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