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Volume 24
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Review

Histone Modifications Represent a Key Epigenetic Feature of Epithelial-to-Mesenchyme Transition in Pancreatic Cancer

by
Ying Xu
and
Qing Zhu
*
Abdominal Oncology Ward, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(5), 4820; https://doi.org/10.3390/ijms24054820
Submission received: 27 December 2022 / Revised: 25 February 2023 / Accepted: 27 February 2023 / Published: 2 March 2023
(This article belongs to the Special Issue Epigenetic Regulation and Cancers)
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Abstract

Pancreatic cancer is one of the most lethal malignant diseases due to its high invasiveness, early metastatic properties, rapid disease progression, and typically late diagnosis. Notably, the capacity for pancreatic cancer cells to undergo epithelial–mesenchymal transition (EMT) is key to their tumorigenic and metastatic potential, and is a feature that can explain the therapeutic resistance of such cancers to treatment. Epigenetic modifications are a central molecular feature of EMT, for which histone modifications are most prevalent. The modification of histones is a dynamic process typically carried out by pairs of reverse catalytic enzymes, and the functions of these enzymes are increasingly relevant to our improved understanding of cancer. In this review, we discuss the mechanisms through which histone-modifying enzymes regulate EMT in pancreatic cancer.
Keywords: pancreatic cancer; epigenetics; histone modification; epithelial-to-mesenchymal transition; pancreatic ductal adenocarcinoma pancreatic cancer; epigenetics; histone modification; epithelial-to-mesenchymal transition; pancreatic ductal adenocarcinoma

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MDPI and ACS Style

Xu, Y.; Zhu, Q. Histone Modifications Represent a Key Epigenetic Feature of Epithelial-to-Mesenchyme Transition in Pancreatic Cancer. Int. J. Mol. Sci. 2023, 24, 4820. https://doi.org/10.3390/ijms24054820

AMA Style

Xu Y, Zhu Q. Histone Modifications Represent a Key Epigenetic Feature of Epithelial-to-Mesenchyme Transition in Pancreatic Cancer. International Journal of Molecular Sciences. 2023; 24(5):4820. https://doi.org/10.3390/ijms24054820

Chicago/Turabian Style

Xu, Ying, and Qing Zhu. 2023. "Histone Modifications Represent a Key Epigenetic Feature of Epithelial-to-Mesenchyme Transition in Pancreatic Cancer" International Journal of Molecular Sciences 24, no. 5: 4820. https://doi.org/10.3390/ijms24054820

APA Style

Xu, Y., & Zhu, Q. (2023). Histone Modifications Represent a Key Epigenetic Feature of Epithelial-to-Mesenchyme Transition in Pancreatic Cancer. International Journal of Molecular Sciences, 24(5), 4820. https://doi.org/10.3390/ijms24054820

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