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Peer-Review Record

IgG1 Is the Optimal Subtype for Treating Atherosclerosis by Inducing M2 Macrophage Differentiation, and Is Independent of the FcγRIIA Gene Polymorphism

Int. J. Mol. Sci. 2023, 24(6), 5932; https://doi.org/10.3390/ijms24065932
by Rui Duan, Yan Liu, Dongmei Tang, Run Lin, Jinrong Huang and Ming Zhao *
Reviewer 1:
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(6), 5932; https://doi.org/10.3390/ijms24065932
Submission received: 27 February 2023 / Revised: 15 March 2023 / Accepted: 15 March 2023 / Published: 21 March 2023
(This article belongs to the Section Molecular Immunology)

Round 1

Reviewer 1 Report

The paper is very interesting and well written. The structure is adequate, the endpoints are well defined. The methodology is adequate and coernet with the endpoints of the study. Results are well described. The discussion is coerent with the results and endpoints. I suggest to discuss the role of VEGF and free radicals in the development of atherosclerosis (see and add as references papers by Murdaca et al concerning these topics) and the potential efficacy of biologics as TNF alpha inhibitors on accelerated atherosclerosis (see and add as references papers by Murdaca et al).

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Dear Authors,

presented work is interesting 

Lin 83-85 should be rewritten to be more clear

line 102 titel should be correctted

line 409 healthy human serum meaning

line 473 statsitic should be bettre explained- on what type of data which statistic i suitable

line 468 m LDL- 468 C, CHO, HDL-C and triglyceride (TG) why these parameters

in results there is part about patient teratement however in methodology there is no part how patients were selected. ist there aethic approval (for mice should be also clear stated)

Best of luck

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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