Circulating Pulmonary-Originated Epithelial Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Search Strategy
2.3. Study Selection
2.4. Data Extraction
2.5. Risk of Bias
2.6. Statistical Analysis
2.6.1. Meta-Analysis of Continuous Variables
2.6.2. Meta-Analysis of Diagnostic Test Accuracy
3. Results
3.1. Literature Search
3.2. Study Characteristics and Quality Assessment
3.3. Biomarkers Associated with ARDS at-Risk Patients’ Identification
3.4. Biomarkers Associated with ARDS Mortality Prediction
3.5. CC16 Diagnosis Test Accuracy
3.6. Publication Bias
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study | Biomarkers | Study Design | Setting | Study Population | ARDS Definition | Study Size | ARDS/ ALI (n) | Age | Male (%) | Plasma Sample Moment |
---|---|---|---|---|---|---|---|---|---|---|
Bersten 1998 [38] | SP-A/SP-B | Observational study | Single center | NM | NM | NM | 10 | NM | NM | NM |
Briassoulis 2006 [22] | KL-6 | Observational study | NM | Critically ill | AECC | 36 | 9 | 8.4 | NM | Within 8 H Of Admission |
Buğra 2020 [40] | SP-D/KL-6 | Observational study | Two centers | COVID-19 patient | Berlin | 88 | 35 | 49 | 47 | At admission |
Determann 2009 [26] | SP-D/KL-6/CC16 | Retrospective observational cohort | Single center | Critically ill | AECC | 37 | 10 | 67 | 70 | Baseline characteristics |
Determann 2010 [41] | SP-D/KL-6/CC16 | RCT | Multicenter | NM | AECC | 36 | 16 | 58 | 50 | At admission |
Gao 2021 [13] | CC16 | Case-control study | Single center | Critically ill | Berlin | 200 | 100 | 56 | 58 | NM |
Gregory 1991 [19] | SP-A/SP-B | Observational study | Multicenter | NM | PaO2/ FiO2 ratio + clinic criteria | 116 | 67 | 45 | 61 | NM |
Kropski 2009 [10] | CC16 | Observational cohort | Single center | Critically ill | AECC | 32 | 23 | 40 | 48 | NM |
Lin 2017 [47] | CC16 | Retrospective observation cohort | Single center | Critically ill | Berlin | 212 | 83 | 54 | 64 | Within 2 h of admission |
Liu 2014 [18] | SP-A | Observational study | Single center | Critically ill | AECC | 60 | 9 | 1.9 | NM | Within 24 h of diagnosis |
Park 2017 [20] | SP-D | Retrospective observation cohort | Multicenter | Critically ill | Berlin | 407 | 39 | 57 | 67 | Within 48 h of ICU admission |
Ren 2016 [39] | SP-A/CC16 | prospective observational study | Single center | Critically ill | Berlin | 212 | 83 | 54 | 67 | Within 2 h of admission |
Sato 2004 [23] | KL-6 | Observational study | NM | Critically ill | AECC | 47 | 28 | 40 | 36 | At ICU admission or at the time of diagnosis |
Todd 2010 [42] | SP-D | Prospective cohort study | NM | PICU | AECC + radiograph | 1165 | 18 | 7 | NM | A total of 12–18 h after ALI diagnosis |
Tojo 2021 [43] | SP-D | Retrospective observational study | Single center | COVID-19 patient | Berlin | 21 | 11 | 69 | 91 | Day 1 in hospital |
Villar 2021 [11] | SP-D | Observational study | Multicenter | Critically ill sepsis | Berlin | 232 | 72 | 60 | 58 | Within 24 h of diagnosis |
Ware 2013 [44] | SP-D/CC16 | Retrospective nested case-control study | Single center | Critically ill sepsis | AECC | 200 | 100 | 56 | 52 | On the morning of ICU day 2 |
Wu 2019 [48] | CC16 | Clinical trial | Single center | Living-donor liver transplantation patient | Bilateral infiltrates + radiograph | 73 | 13 | 59 | 46 | At postoperative day 1 |
Yadav 2018 [45] | SP-D | Prospective observational case-control study | Single center | Adults undergoing elective thoracic, aortic vascular, or cardiac surgery | Berlin | 467 | 26 | 63 | 77 | Immediately follow the major intraoperative insult believed associated with development of lung injury |
Ye 2019 [49] | CC16 | Case-control study | Single center | Critically ill | Berlin | 200 | 100 | 57 | 59 | First day of ARDS diagnosis |
Zeng 2019 [9] | SP-D/KL-6 | Prospective cohort | Two centers | Critically ill | Berlin | 99 | 49 | 53 | 73 | At ICU admission |
Zong 2017 [46] | SP-D | Prospective study | Single center | Critically ill sepsis | Berlin | 88 | 48 | NM | 65 | Within 24 h of ICU admission |
Study | Mortality | Biomarkers | Study Design | Setting | Study Population | ARDS Definition | Study Size | ARDS/ALI (n) | Age | Male (%) | Plasma Sample Moment |
---|---|---|---|---|---|---|---|---|---|---|---|
Eisner 2003 [50] | 38.5 (180D) | SP-A/D | RCT | Multicenter | NM | AECC + radiograph | 565 | 565 | 51 | 59 | Before implementing the ventilator protocol |
Feng 2021 [53] | 32.7 (28D) | CC16 | Observational study | Single center | NM | Berlin | 98 | 98 | 55 | 63 | First day of ARDS diagnosis |
Gao 2021 [13] | 38 (hosp. mort.) | CC16 | Case-control study | Single center | Critically ill | Berlin | 200 | 100 | 56 | 58 | NM |
Han 2015 [51] | 29.1 (28D) | SP-D | Observational study | Single center | Critically ill | AECC | 79 | 79 | NM | NM | Within 24 h of ARDS diagnosis |
Kropski 2009 [10] | 56.5 (ICU) | CC16 | Observational cohort | Single center | Critically ill | AECC | 32 | 23 | 40 | 48 | At emergency department |
Lesur 2006 [54] | 37.2 (28D) | CC16 | Prospective observational study | Multicenter | Critically ill | AECC | 78 | 78 | 63 | 62 | Within 48 h of ARDS diagnosis |
Li 2021 [21] | 30.8 (28D) | KL-6 | Prospective cohort | Single center | Critically ill | Berlin | 65 | 65 | 74 | 63 | Day1 of RICU admission |
Villar 2021 [11] | 34.7 (28D) | SP-D/KL-6 | Observational study | Multicenter | Critically ill sepsis | Berlin | 232 | 72 | 60 | 58 | Within 24 h of diagnosis |
Ware 2013 [44] | 27.3 (hosp. mort.) | SP-D | RCT | Multicenter | NM | AECC + radiograph | 528 | 528 | 50 | 45 | At time of enrolment (prior to randomization) |
Yang 2017 [12] | 44.9 (28D) | SP-D/KL-6 | Observational study | Single center | Critically ill | Berlin | 49 | 49 | NM | NM | The day after ARDS diagnosis |
Zeng 2019 [9] | 34.7 (28D) | SP-D/KL-6 | Prospective cohort | Two centers | Critically ill | Berlin | 99 | 49 | 53 | 73 | At time of ARDS diagnosis |
Zhi 2016 [52] | 30.7 (28D) | SP-A/SP-D/CC16 | Retrospective study | Single center | Critically ill | AECC | 101 | 101 | 56 | 46 | Within 24 h of admission |
Study | AUC | Study Design | Setting | Study Population | ARDS Definition | Study Size | ARDS/ ALI (n) | Age | Male (%) | Plasma Sample Moment |
---|---|---|---|---|---|---|---|---|---|---|
Determann 2009 [26] | 0.91 | Retrospective observational cohort | Single center | Critically ill | AECC | 37 | 10 | 67 | 70 | Baseline characteristics |
Gao 2021 [13] | 0.75 | Case-control study | Single center | Critically ill | Berlin | 200 | 100 | 56 | 58 | NM |
Lin 2020 [25] | 0.87 | Observational cohort | Single center | Critically ill | Berlin | 479 | 83 | 52 | 58 | Within 3 h of admission |
Wang 2017 [55] | 0.86 | Prospective cohort | Multicenter | Critically ill sepsis | Berlin | 100 | 59 | NM | 67 | At admission |
Ware 2013 [44] | 0.60 | Retrospective nested case-control study | Single center | Critically ill sepsis | AECC | 200 | 100 | 56 | 52 | On the morning of ICU day 2 |
Wu 2019 [48] | 0.80 | Clinical trial | Single center | Living-donor liver transplantation patient | Berlin | 73 | 13 | 59 | 46 | At postoperative day 1 |
Ye 2019 [49] | 0.74 | Case-control study | Single center | Critically ill | Berlin | 200 | 100 | 57 | 59 | First day of ARDS diagnosis |
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Lin, H.; Liu, Q.; Zhao, L.; Liu, Z.; Cui, H.; Li, P.; Fan, H.; Guo, L. Circulating Pulmonary-Originated Epithelial Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2023, 24, 6090. https://doi.org/10.3390/ijms24076090
Lin H, Liu Q, Zhao L, Liu Z, Cui H, Li P, Fan H, Guo L. Circulating Pulmonary-Originated Epithelial Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2023; 24(7):6090. https://doi.org/10.3390/ijms24076090
Chicago/Turabian StyleLin, Huishu, Qisijing Liu, Lei Zhao, Ziquan Liu, Huanhuan Cui, Penghui Li, Haojun Fan, and Liqiong Guo. 2023. "Circulating Pulmonary-Originated Epithelial Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 24, no. 7: 6090. https://doi.org/10.3390/ijms24076090