Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Experimental Design
4.2. Epigenetic Clock Analysis
4.3. Measurement of Clinical Frailty Index, Physical Function Score and Vitality Score
4.4. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Females | Males | |||
---|---|---|---|---|
F | p | F | p | |
ΔCFI (t1 − t0) | 1.143 | 0.145 | 4.124 | 0.048 |
ΔCFI (t2 − t0) | 6.019 | 0.020 | 1.879 | 0.177 |
ΔCFI (t3 − t0) | 0.295 | 0.592 | 1.372 | 0.248 |
ΔPFS (t1 − t0) | 0.834 | 0.368 | 2.966 | 0.091 |
ΔPFS (t2 − t0) | 13.235 | 0.001 | 6.689 | 0.013 |
ΔPFS (t3 − t0) | 0.001 | 0.991 | 10.210 | 0.003 |
ΔVS (t1 − t0) | 1.378 | 0.250 | 5.221 | 0.027 |
ΔVS (t2 − t0) | 13.146 | 0.001 | 6.098 | 0.017 |
ΔVS (t3 − t0) | 0.036 | 0.852 | 5.117 | 0.029 |
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Giuliani, M.E.; Barbi, V.; Bigossi, G.; Marcozzi, S.; Giacconi, R.; Cardelli, M.; Piacenza, F.; Orlando, F.; Ciaglia, E.; Cattaneo, M.; et al. Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice. Int. J. Mol. Sci. 2023, 24, 6464. https://doi.org/10.3390/ijms24076464
Giuliani ME, Barbi V, Bigossi G, Marcozzi S, Giacconi R, Cardelli M, Piacenza F, Orlando F, Ciaglia E, Cattaneo M, et al. Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice. International Journal of Molecular Sciences. 2023; 24(7):6464. https://doi.org/10.3390/ijms24076464
Chicago/Turabian StyleGiuliani, Maria Elisa, Veronica Barbi, Giorgia Bigossi, Serena Marcozzi, Robertina Giacconi, Maurizio Cardelli, Francesco Piacenza, Fiorenza Orlando, Elena Ciaglia, Monica Cattaneo, and et al. 2023. "Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice" International Journal of Molecular Sciences 24, no. 7: 6464. https://doi.org/10.3390/ijms24076464