To Gain Insights into the Pathophysiological Mechanisms of the Thrombo-Inflammatory Process in the Atherosclerotic Plaque
Abstract
:1. Introduction
Search Strategy
2. Understanding the Role of Platelets and P-Selectin as Key Actors in Thromboinflammation
3. Interaction of NETs with Ultra-Large VWF in Thromboinflammatory Vasculopathy
3.1. Identifying the Role Played by NETs
3.2. The Role of VWF and ADAMTS13
3.3. Inflammasone to the Direction of All Actors
4. Focusing on the Thromboinflammation Process in Atherosclerosis and COVID-19
4.1. Implication of Atherosclerosis
4.2. Implication of Thromboinflammation in COVID-19
5. Nex Steps
6. Limitation
7. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Therapeutic Agent/Drug Name | Indication | Study No./Status | Preclinical/Clinical Study Outcome | Refs. |
---|---|---|---|---|
Crizanlizumab | P-selectin inhibitor | NCT03814746 | No improvement in clinical outcomes | [161] |
Pulmozyme | Reduces NETosis in neutrophils. | NCT04402944 | Phase 2 | [166] |
Targeting Chi3l1 | Advanced cancer. Enhance anti-tumor immunity | “ ” “ ” | Reduced levels of helper and cytotoxic T cells in TNBC tumors led to decreased tumor infiltration. | [177] |
Danirixin hydrobromide | Reduces NETs formation | NCT02453022 | Phase 1 | [178,179] |
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Nappi, F. To Gain Insights into the Pathophysiological Mechanisms of the Thrombo-Inflammatory Process in the Atherosclerotic Plaque. Int. J. Mol. Sci. 2024, 25, 47. https://doi.org/10.3390/ijms25010047
Nappi F. To Gain Insights into the Pathophysiological Mechanisms of the Thrombo-Inflammatory Process in the Atherosclerotic Plaque. International Journal of Molecular Sciences. 2024; 25(1):47. https://doi.org/10.3390/ijms25010047
Chicago/Turabian StyleNappi, Francesco. 2024. "To Gain Insights into the Pathophysiological Mechanisms of the Thrombo-Inflammatory Process in the Atherosclerotic Plaque" International Journal of Molecular Sciences 25, no. 1: 47. https://doi.org/10.3390/ijms25010047