Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF
Abstract
:1. Introduction
2. Results
2.1. Decreased BrdU+ and BrdU+/DCX+ Cells in the DG of Aβ1–42 Mice Are Reversed via Curcumin Treatment
2.2. Decreased BrdU+ and BrdU+/NeuN+ Cells in the DG of Aβ1–42 Mice Are Reversed by Curcumin Treatment
2.3. Curcumin Upregulates Wnt/β-Catenin Signaling and BDNF Content
2.4. Curcumin Upregulated Wnt/β-Catenin and BDNF Aβ1–42 Mice through the PI3K/Akt Pathway
2.5. Curcumin-Upregulated Neurogenesis in Aβ1–42 Mice via Enhancing β-Catenin and BDNF
2.6. Curcumin Can Improve the Cognitive Function of Aβ1–42 Mice by Enhancing Wnt/β-Catenin and BDNF
3. Discussion
3.1. The Regulatory Role of Wnt/β-Catenin in Adult Neurogenesis
3.2. The Vital Role of PI3K/Akt in the Improvement of Neurogenesis via Curcumin Treatment in Aβ1–42 Mice
4. Materials and Methods
4.1. Experimental Animals
4.2. AD Model Preparation
4.3. Drug Administration
4.4. Western Blotting
4.5. Immunochemistry Examination
4.6. Enzyme-Linked Immunosorbent Assay (ELISA)
4.7. Morris Water Maze
4.8. Inclusion and Exclusion Criteria
4.9. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Lou, S.; Gong, D.; Yang, M.; Qiu, Q.; Luo, J.; Chen, T. Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF. Int. J. Mol. Sci. 2024, 25, 5123. https://doi.org/10.3390/ijms25105123
Lou S, Gong D, Yang M, Qiu Q, Luo J, Chen T. Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF. International Journal of Molecular Sciences. 2024; 25(10):5123. https://doi.org/10.3390/ijms25105123
Chicago/Turabian StyleLou, Shengchun, Danfeng Gong, Mengting Yang, Qing Qiu, Jialie Luo, and Tingting Chen. 2024. "Curcumin Improves Neurogenesis in Alzheimer’s Disease Mice via the Upregulation of Wnt/β-Catenin and BDNF" International Journal of Molecular Sciences 25, no. 10: 5123. https://doi.org/10.3390/ijms25105123