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Article

A Well-Established Gut Microbiota Enhances the Efficiency of Nutrient Metabolism and Improves the Growth Performance of Trachinotus ovatus

by
Miao Kong
1,2,
Wendong Zhao
1,2,
Cong Wang
1,2,
Jie Qi
1,2,
Jinxiang Liu
1,2 and
Quanqi Zhang
1,2,*
1
Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya 572025, China
2
MOE Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao 266003, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(10), 5525; https://doi.org/10.3390/ijms25105525
Submission received: 9 April 2024 / Revised: 14 May 2024 / Accepted: 16 May 2024 / Published: 18 May 2024
(This article belongs to the Special Issue Microbial Omics)
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Abstract

The gut microbiota has become an essential component of the host organism and plays a crucial role in the host immune system, metabolism, and physiology. Nevertheless, our comprehension of how the fish gut microbiota contributes to enhancing nutrient utilization in the diet and improving host growth performance remains unclear. In this study, we employed a comprehensive analysis of the microbiome, metabolome, and transcriptome to analyze intestines of the normal control group and the antibiotic-treated model group of T. ovatus to investigate how the gut microbiota enhances fish growth performance and uncover the underlying mechanisms. First, we found that the growth performance of the control group was significantly higher than that of the antibiotic-treated model under the same feeding conditions. Subsequent multiomics analyses showed that the gut microbiota can improve its own composition by mediating the colonization of some probiotics represented by Lactobacillus in the intestine, improving host metabolic efficiency with proteins and lipids, and also influencing the expression of genes in signaling pathways related to cell proliferation, which together contribute to the improved growth performance of T. ovatus. Our results demonstrated the important contribution of gut microbiota and its underlying molecular mechanisms on the growth performance of T. ovatus.
Keywords: gut microbiota; growth; antibiotic-treated; multiomics analysis; Trachinotus ovatus gut microbiota; growth; antibiotic-treated; multiomics analysis; Trachinotus ovatus

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MDPI and ACS Style

Kong, M.; Zhao, W.; Wang, C.; Qi, J.; Liu, J.; Zhang, Q. A Well-Established Gut Microbiota Enhances the Efficiency of Nutrient Metabolism and Improves the Growth Performance of Trachinotus ovatus. Int. J. Mol. Sci. 2024, 25, 5525. https://doi.org/10.3390/ijms25105525

AMA Style

Kong M, Zhao W, Wang C, Qi J, Liu J, Zhang Q. A Well-Established Gut Microbiota Enhances the Efficiency of Nutrient Metabolism and Improves the Growth Performance of Trachinotus ovatus. International Journal of Molecular Sciences. 2024; 25(10):5525. https://doi.org/10.3390/ijms25105525

Chicago/Turabian Style

Kong, Miao, Wendong Zhao, Cong Wang, Jie Qi, Jinxiang Liu, and Quanqi Zhang. 2024. "A Well-Established Gut Microbiota Enhances the Efficiency of Nutrient Metabolism and Improves the Growth Performance of Trachinotus ovatus" International Journal of Molecular Sciences 25, no. 10: 5525. https://doi.org/10.3390/ijms25105525

APA Style

Kong, M., Zhao, W., Wang, C., Qi, J., Liu, J., & Zhang, Q. (2024). A Well-Established Gut Microbiota Enhances the Efficiency of Nutrient Metabolism and Improves the Growth Performance of Trachinotus ovatus. International Journal of Molecular Sciences, 25(10), 5525. https://doi.org/10.3390/ijms25105525

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