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Volume 25
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Review

Long Non-Coding RNAs in Neuroblastoma: Pathogenesis, Biomarkers and Therapeutic Targets

by
Niels Vercouillie
1,
Zhiyao Ren
1,2,3,
Eva Terras
1,2,3 and
Tim Lammens
1,2,3,*
1
Department of Internal Medicine and Pediatrics, Ghent University, 9000 Ghent, Belgium
2
Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, 9000 Ghent, Belgium
3
Cancer Research Institute Ghent, 9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(11), 5690; https://doi.org/10.3390/ijms25115690
Submission received: 18 April 2024 / Revised: 18 May 2024 / Accepted: 21 May 2024 / Published: 23 May 2024
(This article belongs to the Special Issue RNA in Biology and Medicine)
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Abstract

Neuroblastoma is the most common malignant extracranial solid tumor of childhood. Recent studies involving the application of advanced high-throughput “omics” techniques have revealed numerous genomic alterations, including aberrant coding-gene transcript levels and dysfunctional pathways, that drive the onset, growth, progression, and treatment resistance of neuroblastoma. Research conducted in the past decade has shown that long non-coding RNAs, once thought to be transcriptomic noise, play key roles in cancer development. With the recent and continuing increase in the amount of evidence for the underlying roles of long non-coding RNAs in neuroblastoma, the potential clinical implications of these RNAs cannot be ignored. In this review, we discuss their biological mechanisms of action in the context of the central driving mechanisms of neuroblastoma, focusing on potential contributions to the diagnosis, prognosis, and treatment of this disease. We also aim to provide a clear, integrated picture of future research opportunities.
Keywords: long non-coding RNA; neuroblastoma; cancer hallmark; diagnostic; prognostic; therapy long non-coding RNA; neuroblastoma; cancer hallmark; diagnostic; prognostic; therapy

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MDPI and ACS Style

Vercouillie, N.; Ren, Z.; Terras, E.; Lammens, T. Long Non-Coding RNAs in Neuroblastoma: Pathogenesis, Biomarkers and Therapeutic Targets. Int. J. Mol. Sci. 2024, 25, 5690. https://doi.org/10.3390/ijms25115690

AMA Style

Vercouillie N, Ren Z, Terras E, Lammens T. Long Non-Coding RNAs in Neuroblastoma: Pathogenesis, Biomarkers and Therapeutic Targets. International Journal of Molecular Sciences. 2024; 25(11):5690. https://doi.org/10.3390/ijms25115690

Chicago/Turabian Style

Vercouillie, Niels, Zhiyao Ren, Eva Terras, and Tim Lammens. 2024. "Long Non-Coding RNAs in Neuroblastoma: Pathogenesis, Biomarkers and Therapeutic Targets" International Journal of Molecular Sciences 25, no. 11: 5690. https://doi.org/10.3390/ijms25115690

APA Style

Vercouillie, N., Ren, Z., Terras, E., & Lammens, T. (2024). Long Non-Coding RNAs in Neuroblastoma: Pathogenesis, Biomarkers and Therapeutic Targets. International Journal of Molecular Sciences, 25(11), 5690. https://doi.org/10.3390/ijms25115690

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