Research on the Medicinal Chemistry and Pharmacology of Taxus × media
Abstract
:1. Introduction
2. Origin and Cultivation
2.1. Origin and Geographical Distribution
2.2. Artificial Cultivation and Comparative Analysis
3. Phytochemical Constituents
3.1. Chemical Composition of Different Parts of Taxus × media
3.1.1. Chemical Composition of Taxus × media Leaves and Twigs
3.1.2. Chemical Composition of Taxus × media Barks
3.1.3. Chemical Composition of Taxus × media Seeds
3.2. The Impact of Origin and Growth Duration on the Variation of Active Components in Taxus × media
3.3. Comparison of Chemical Components between Taxus × media and Other Taxus Species
4. Pharmacological Activity
4.1. Anticancer Activity
4.1.1. Anticancer Activity of Monomeric Compounds
Taxane Compounds
Other Non-Taxane Anticancer Components
4.1.2. Anticancer Activity of Extracts
4.2. Antibacterial Activity
4.3. Anti-Diabetic Activity
4.4. Anti-Inflammatory Activity
4.5. Antioxidant Activity
5. Discussion and Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Bioactive Constituents | Molecular Weight | CAS | Chemical Structure | Source | Content | Reference |
---|---|---|---|---|---|---|
Paclitaxel | 853.9 g/mol | 33069-62-4 | C47H51NO14 | The leaves, needles and barks of Taxus × media | 0.13–0.60 mg/g | [2,26,27] |
Cephalomannine | 831.9 g/mol | 71610-00-9 | C5H53NO14 | The leaves, needles and barks of Taxus × media | 0. 053 mg/g | [2] |
Baccatine III | 586.6 g/mol | 27548-93-2 | C31H38O11 | The needles of Taxus × media | 0.13–0.31 mg/g | [26] |
10-DAB | 544.6 g/mol | 32981-86-5 | C29H36O10 | The leaves and needles of Taxus × media | 0.24–0.78 mg/g | [28,29] |
Taxinine | 606.7 g/mol | 3835-52-7 | C35H42O9 | The needles and bark of Taxus × media | [30] | |
Taxinine A | 476.6 g/mol | 18530-09-1 | C26H36O8 | The seeds and needles of Taxus × media | [30,31] | |
9-Deacetyltaxinine E | 608.7 g/mol | 284672-78-2 | C35H44O9 | The seeds of Taxus × media | [32] | |
10-DAT | 544.6 g/mol | 32981-86-5 | C29H36O10 | The needles of Taxus × media | 0. 126 mg/g | [33] |
7-epi-10-DAT | 544.6 g/mol | 7162-920 | C29H36O10 | The needles of Taxus × media | 0.033 mg/g | [2] |
7-Xylosyl-10-deacetyltaxol | 944.0 g/mol | 90332-63-1 | C50H57NO17 | The needles of Taxus × media | 0.315 mg/g | [34,35] |
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Gao, X.; Zhang, N.; Xie, W. Research on the Medicinal Chemistry and Pharmacology of Taxus × media. Int. J. Mol. Sci. 2024, 25, 5756. https://doi.org/10.3390/ijms25115756
Gao X, Zhang N, Xie W. Research on the Medicinal Chemistry and Pharmacology of Taxus × media. International Journal of Molecular Sciences. 2024; 25(11):5756. https://doi.org/10.3390/ijms25115756
Chicago/Turabian StyleGao, Xinyu, Ni Zhang, and Weidong Xie. 2024. "Research on the Medicinal Chemistry and Pharmacology of Taxus × media" International Journal of Molecular Sciences 25, no. 11: 5756. https://doi.org/10.3390/ijms25115756