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Review

The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review

by
Jayant Seth
1,†,
Sohat Sharma
1,†,
Cameron J. Leong
1,
Venkat Vaibhav
2,
Pierce Nelson
2,
Arveen Shokravi
1,
Yuchen Luo
1,
Daniel Shirvani
1 and
Zachary Laksman
1,3,4,*
1
Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
2
Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada
3
School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
4
Centre for Heart Lung Innovation, St. Paul’s Hospital, Vancouver, BC V6Z 1Y6, Canada
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(12), 6634; https://doi.org/10.3390/ijms25126634
Submission received: 14 April 2024 / Revised: 4 June 2024 / Accepted: 12 June 2024 / Published: 17 June 2024
(This article belongs to the Special Issue Advanced Research in Stem Cell and Exosome-Based Therapy)
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Abstract

The purpose of this review is to summarize the current understanding of the therapeutic effect of stem cell-based therapies, including hematopoietic stem cells, for the treatment of ischemic heart damage. Following PRISMA guidelines, we conducted electronic searches in MEDLINE, and EMBASE. We screened 592 studies, and included RCTs, observational studies, and cohort studies that examined the effect of hematopoietic stem cell therapy in adult patients with heart failure. Studies that involved pediatric patients, mesenchymal stem cell therapy, and non-heart failure (HF) studies were excluded from our review. Out of the 592 studies, 7 studies met our inclusion criteria. Overall, administration of hematopoietic stem cells (via intracoronary or myocardial infarct) led to positive cardiac outcomes such as improvements in pathological left-ventricular remodeling, perfusion following acute myocardial infarction, and NYHA symptom class. Additionally, combined death, rehospitalization for heart failure, and infarction were significantly lower in patients treated with bone marrow-derived hematopoietic stem cells. Our review demonstrates that hematopoietic stem cell administration can lead to positive cardiac outcomes for HF patients. Future studies should aim to increase female representation and non-ischemic HF patients.
Keywords: stem cell therapy; hematopoietic; heart failure; clinical; ischemic heart damage stem cell therapy; hematopoietic; heart failure; clinical; ischemic heart damage

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MDPI and ACS Style

Seth, J.; Sharma, S.; Leong, C.J.; Vaibhav, V.; Nelson, P.; Shokravi, A.; Luo, Y.; Shirvani, D.; Laksman, Z. The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review. Int. J. Mol. Sci. 2024, 25, 6634. https://doi.org/10.3390/ijms25126634

AMA Style

Seth J, Sharma S, Leong CJ, Vaibhav V, Nelson P, Shokravi A, Luo Y, Shirvani D, Laksman Z. The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review. International Journal of Molecular Sciences. 2024; 25(12):6634. https://doi.org/10.3390/ijms25126634

Chicago/Turabian Style

Seth, Jayant, Sohat Sharma, Cameron J. Leong, Venkat Vaibhav, Pierce Nelson, Arveen Shokravi, Yuchen Luo, Daniel Shirvani, and Zachary Laksman. 2024. "The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review" International Journal of Molecular Sciences 25, no. 12: 6634. https://doi.org/10.3390/ijms25126634

APA Style

Seth, J., Sharma, S., Leong, C. J., Vaibhav, V., Nelson, P., Shokravi, A., Luo, Y., Shirvani, D., & Laksman, Z. (2024). The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review. International Journal of Molecular Sciences, 25(12), 6634. https://doi.org/10.3390/ijms25126634

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