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Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions
by
Merin Lawrence
Merin Lawrence 1,†,
Abhishek Goyal
Abhishek Goyal 2,†
,
Shelly Pathak
Shelly Pathak 3 and
Payal Ganguly
Payal Ganguly 4,*
1
School of Biological and Chemical Sciences, University of Galway, H91W2TY Galway, Ireland
2
RAS Life Science Solutions, Stresemannallee 61, 60596 Frankfurt, Germany
3
Observational and Pragmatic Research Institute, 5 Coles Lane, Oakington, CB24 3BA, Cambridge, UK
4
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds LS9 7JT, UK
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to the manuscript.
Int. J. Mol. Sci. 2024, 25(13), 7411; https://doi.org/10.3390/ijms25137411 (registering DOI)
Submission received: 31 May 2024
/
Revised: 22 June 2024
/
Accepted: 3 July 2024
/
Published: 5 July 2024
Abstract
Advancing age is associated with several age-related diseases (ARDs), with musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic conditions contributing towards considerable number of patients, a deeper understanding of bone aging is the need of the hour. One of the underlying factors of bone aging is cellular senescence and its associated senescence associated secretory phenotype (SASP). SASP comprises of pro-inflammatory markers, cytokines and chemokines that arrest cell growth and development. The accumulation of SASP over several years leads to chronic low-grade inflammation with advancing age, also known as inflammaging. The pathways and molecular mechanisms focused on bone senescence and inflammaging are currently limited but are increasingly being explored. Most of the genes, pathways and mechanisms involved in senescence and inflammaging coincide with those associated with cancer and other ARDs like osteoarthritis (OA). Thus, exploring these pathways using techniques like sequencing, identifying these factors and combatting them with the most suitable approach are crucial for healthy aging and the early detection of ARDs. Several approaches can be used to aid regeneration and reduce senescence in the bone. These may be pharmacological, non-pharmacological and lifestyle interventions. With increasing evidence towards the intricate relationship between aging, senescence, inflammation and ARDs, these approaches may also be used as anti-aging strategies for the aging bone marrow (BM).
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MDPI and ACS Style
Lawrence, M.; Goyal, A.; Pathak, S.; Ganguly, P.
Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions. Int. J. Mol. Sci. 2024, 25, 7411.
https://doi.org/10.3390/ijms25137411
AMA Style
Lawrence M, Goyal A, Pathak S, Ganguly P.
Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions. International Journal of Molecular Sciences. 2024; 25(13):7411.
https://doi.org/10.3390/ijms25137411
Chicago/Turabian Style
Lawrence, Merin, Abhishek Goyal, Shelly Pathak, and Payal Ganguly.
2024. "Cellular Senescence and Inflammaging in the Bone: Pathways, Genetics, Anti-Aging Strategies and Interventions" International Journal of Molecular Sciences 25, no. 13: 7411.
https://doi.org/10.3390/ijms25137411
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