Termite Fungus Comb Polysaccharides Alleviate Hyperglycemia and Hyperlipidemia in Type 2 Diabetic Mice by Regulating Hepatic Glucose/Lipid Metabolism and the Gut Microbiota
Abstract
:1. Introduction
2. Results
2.1. Extraction and Characterization of TFCPs
2.2. TFCPs Improve Systemic Glucose and Lipid Homeostasis in T2D Mice
2.3. TFCPs Ameliorate the Morphology and Function of Pancreatic Islets in T2D Mice
2.4. TFCPs Enhance Hepatic Glucose Metabolism in T2D Mice
2.5. TFCPs Boost Hepatic Lipid Metabolism in T2D Mice
2.6. TFCPs Optimize the Diversity and Composition of Gut Microbiota in T2D Mice
2.7. TFCPs Modify the Function of Gut Microbiota in T2D Mice
3. Discussion
4. Materials and Methods
4.1. TFCP Preparation
4.2. Chemical Analysis of TFCPs
4.3. Animal Studies and Experimental Protocols
4.4. OGTT
4.5. Biochemical Assay
4.6. Histological Examinations
4.7. RNA Extraction and qRT-PCR
4.8. Fecal Microbiome Analysis
4.9. Data Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mn | Mp | Mw | Mz | Mw/Mn | |
---|---|---|---|---|---|
(kDa) | 23.593 | 17.923 | 58.917 | 1452.528 | 2.497 |
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Xiao, H.; Song, X.; Wang, P.; Li, W.; Qin, S.; Huang, C.; Wu, B.; Jia, B.; Gao, Q.; Song, Z. Termite Fungus Comb Polysaccharides Alleviate Hyperglycemia and Hyperlipidemia in Type 2 Diabetic Mice by Regulating Hepatic Glucose/Lipid Metabolism and the Gut Microbiota. Int. J. Mol. Sci. 2024, 25, 7430. https://doi.org/10.3390/ijms25137430
Xiao H, Song X, Wang P, Li W, Qin S, Huang C, Wu B, Jia B, Gao Q, Song Z. Termite Fungus Comb Polysaccharides Alleviate Hyperglycemia and Hyperlipidemia in Type 2 Diabetic Mice by Regulating Hepatic Glucose/Lipid Metabolism and the Gut Microbiota. International Journal of Molecular Sciences. 2024; 25(13):7430. https://doi.org/10.3390/ijms25137430
Chicago/Turabian StyleXiao, Haihan, Xudong Song, Peng Wang, Weilin Li, Senhua Qin, Chaofu Huang, Beimin Wu, Bao Jia, Qionghua Gao, and Ziyi Song. 2024. "Termite Fungus Comb Polysaccharides Alleviate Hyperglycemia and Hyperlipidemia in Type 2 Diabetic Mice by Regulating Hepatic Glucose/Lipid Metabolism and the Gut Microbiota" International Journal of Molecular Sciences 25, no. 13: 7430. https://doi.org/10.3390/ijms25137430