Next Article in Journal
Chalcogen Noncovalent Interactions between Diazines and Sulfur Oxides in Supramolecular Circular Chains
Previous Article in Journal
Inhibition of Indoleamine 2,3-Dioxygenase Exerts Antidepressant-like Effects through Distinct Pathways in Prelimbic and Infralimbic Cortices in Rats under Intracerebroventricular Injection with Streptozotocin
Previous Article in Special Issue
EWS/FLI1 Characterization, Activation, Repression, Target Genes and Therapeutic Opportunities in Ewing Sarcoma
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 25
Issue 13
10.3390/ijms25137495
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Survival Difference of Endometrial Cancer Patients with Peritoneal Metastasis Receiving Cytoreductive Surgery (CRS) with and without Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Systematic Review and Meta-Analysis

by
Ivan Panczel
1,
Miklos Acs
2,
Magdolna Herold
1,3,
Viktor Madar-Dank
4,
Pompiliu Piso
5,
Hans Jürgen Schlitt
2,
Magdolna Dank
1,
Attila Marcell Szasz
1,*,† and
Zoltan Herold
1,†
1
Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, H-1083 Budapest, Hungary
2
Department of Surgery, University Medical Center Regensburg, D-93053 Regensburg, Germany
3
Department of Internal Medicine and Hematology, Semmelweis University, H-1088 Budapest, Hungary
4
Department of Finance, Rutgers University, Newark, NJ 07102, USA
5
Department of General and Visceral Surgery, Hospital Barmherzige Brüder, D-93049 Regensburg, Germany
*
Author to whom correspondence should be addressed.
†
Szasz, A.M. and Herold, Z. share senior authorship.
Int. J. Mol. Sci. 2024, 25(13), 7495; https://doi.org/10.3390/ijms25137495
Submission received: 11 June 2024 / Revised: 4 July 2024 / Accepted: 6 July 2024 / Published: 8 July 2024
(This article belongs to the Special Issue Novel Therapeutic Targets of Solid Cancer)
Review Reports Versions Notes

Abstract

Although several studies have been completed to investigate the effect of cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) in endometrial cancer with peritoneal metastasis (ECPM), a direct comparison was not performed previously. A meta-analysis was performed to investigate the suspected additional survival benefits of CRS plus HIPEC over CRS only. Twenty-one and ten studies with a total number of 1116 and 152 cases investigating CRS only and CRS plus HIPEC were identified, respectively. When all articles were analyzed, the 1-year survival rate was 17.60% higher for CRS plus HIPEC (82.28% vs. 64.68%; p = 0.0102). The same tendency was observed for the 2-year (56.07% vs. 36.95%; difference: 19.12%; p = 0.0014), but not for the 5-year (21.88% vs. 16.45%; difference: 5.43%; p = 0.3918) survival rates. The same clinical significance, but statistically less strong observations, could be made if only the studies published after 2010 were investigated (1-year survival rate: 12.08% and p = 0.0648; 2-year survival rate: 10.90% and p = 0.0988). CRS remains one of the core elements of ECPM treatment, but the addition of HIPEC to CRS can increase the positive clinical outcome, especially in the first 2 years.
Keywords: cytoreduction surgical procedures; endometrial neoplasms; hyperthermic intraperitoneal chemotherapy; peritoneal metastasis cytoreduction surgical procedures; endometrial neoplasms; hyperthermic intraperitoneal chemotherapy; peritoneal metastasis

Share and Cite

MDPI and ACS Style

Panczel, I.; Acs, M.; Herold, M.; Madar-Dank, V.; Piso, P.; Schlitt, H.J.; Dank, M.; Szasz, A.M.; Herold, Z. Survival Difference of Endometrial Cancer Patients with Peritoneal Metastasis Receiving Cytoreductive Surgery (CRS) with and without Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2024, 25, 7495. https://doi.org/10.3390/ijms25137495

AMA Style

Panczel I, Acs M, Herold M, Madar-Dank V, Piso P, Schlitt HJ, Dank M, Szasz AM, Herold Z. Survival Difference of Endometrial Cancer Patients with Peritoneal Metastasis Receiving Cytoreductive Surgery (CRS) with and without Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2024; 25(13):7495. https://doi.org/10.3390/ijms25137495

Chicago/Turabian Style

Panczel, Ivan, Miklos Acs, Magdolna Herold, Viktor Madar-Dank, Pompiliu Piso, Hans Jürgen Schlitt, Magdolna Dank, Attila Marcell Szasz, and Zoltan Herold. 2024. "Survival Difference of Endometrial Cancer Patients with Peritoneal Metastasis Receiving Cytoreductive Surgery (CRS) with and without Hyperthermic Intraperitoneal Chemotherapy (HIPEC): A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 25, no. 13: 7495. https://doi.org/10.3390/ijms25137495

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop