Platelet Contribution and Endothelial Activation and Stress Index-Potential Mortality Predictors in Traumatic Brain Injury
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | Survivor (n = 44) | Non-Survivor (n = 19) | p Value—Two Tailed |
---|---|---|---|
Age (years) * | 40.64 ± 15.04 | 44.95 ± 15.84 | 0.30 |
BMI (kg/m2) * | 26.11 ± 4.20 | 25.12 ± 3.90 | 0.38 |
Severe TBI *** | n = 34 (77.27%) | n = 16 (84.21%) | 0.73 |
Moderate TBI *** | n = 10 (22.73%) | n = 3 (15.79%) | |
Epidural hematoma *** | 7 (15.91%) | 2 (10.53%) | 0.71 |
Subdural hematoma *** | 10 (22.73%) | 8(42.11%) | 0.13 |
Subarachnoid hemorrhage *** | 26 (52.63%) | 10 (59.09%) | 0.78 |
pH * | 7.28 ± 0.10 | 7.22 ± 0.15 | 0.07 |
Base excess (mmol/L) * | −7.03 ± 6.99 | −11.90 ± 10.85 | 0.03 |
Serum lactate ** (mmol/L) | 2.10 (1.1–3.4) | 2.60 (0.6–6) | 0.29 |
Serum bicarbonate (mmol/L) * | 19.70 ± 4.11 | 20.00 ± 5.73 | 0.81 |
Hemoglobin (g/dL) ** | 9.60 (8.7–11.60) | 9.30 (8.8–10.70) | 0.72 |
Platelets/µL ** | 189,000 (143,000–298,000) | 108,000 (89,000–151,000) | <0.0001 |
INR ** | 1.76 (1.11–2.46) | 2.40 (1.22–3.56) | 0.02 |
aPTT (sec) * | 36.16 ± 7.40 | 39.11 ± 7.80 | 0.15 |
EXTEM A5 (mm) * | 38.2 ± 3.18 | 28.95 ± 5.89 | <0.0001 |
EXTEM A10 (mm) * | 47.59 ± 3.28 | 38.11 ± 6.02 | <0.0001 |
EXTEM A20 (mm) * | 56.14 ± 3.40 | 45.37 ± 6.68 | <0.0001 |
EXTEM MCF (mm) * | 59.86 ± 2.80 | 50.05 ± 5.99 | <0.0001 |
FIBTEM A5 (mm) * | 9.61 ± 1.79 | 6.78 ± 2.41 | <0.0001 |
FIBTEM A10 (mm) * | 11.11 ± 1.94 | 7.94 ± 2.65 | <0.0001 |
FIBTEM A20 (mm) * | 13.52 ± 2.17 | 10.16 ± 2.63 | <0.0001 |
FIBTEM MCF (mm) * | 15.20 ± 2.25 | 11.53 ± 2.93 | <0.0001 |
LDH (U/L) ** | 348.50 (303.00–423.5) | 484.00 (411.00–624.00) | <0.0001 |
Serum creatinine (mg/dL) ** | 0.64 (0.60–0.73) | 0.82 (0.74–0.82) | <0.0001 |
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Băetu, A.E.; Mirea, L.E.; Cobilinschi, C.; Grințescu, I.C.; Grințescu, I.M. Platelet Contribution and Endothelial Activation and Stress Index-Potential Mortality Predictors in Traumatic Brain Injury. Int. J. Mol. Sci. 2024, 25, 7763. https://doi.org/10.3390/ijms25147763
Băetu AE, Mirea LE, Cobilinschi C, Grințescu IC, Grințescu IM. Platelet Contribution and Endothelial Activation and Stress Index-Potential Mortality Predictors in Traumatic Brain Injury. International Journal of Molecular Sciences. 2024; 25(14):7763. https://doi.org/10.3390/ijms25147763
Chicago/Turabian StyleBăetu, Alexandru Emil, Liliana Elena Mirea, Cristian Cobilinschi, Ioana Cristina Grințescu, and Ioana Marina Grințescu. 2024. "Platelet Contribution and Endothelial Activation and Stress Index-Potential Mortality Predictors in Traumatic Brain Injury" International Journal of Molecular Sciences 25, no. 14: 7763. https://doi.org/10.3390/ijms25147763