Western Diet Modifies Platelet Activation Profiles in Male Mice
Abstract
:1. Introduction
2. Results
2.1. Body Mass and Composition Changes Resulting from a Western Diet
2.2. Platelet Receptor Expression Changes in the Total Population as a Result of the Western Diet
2.3. Receptor Expression within Stimulated Platelet Subpopulations Influenced by Western Diet
2.4. Body Mass Demonstrates No Correlation with GPIbα or αIIbβ3 Expression
2.5. Fat Mass Does Not Correlate with Platelet Receptor Expression
3. Discussion
4. Materials and Methods
4.1. Mouse Model and Diet Administration
4.2. Blood Collection
4.3. Platelet Rich Plasma Generation and Stimulation
4.4. Flow Cytometry Preparation, Acquisition and Analysis
4.5. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Corken, A.; Wahl, E.C.; Sikes, J.D.; Thakali, K.M. Western Diet Modifies Platelet Activation Profiles in Male Mice. Int. J. Mol. Sci. 2024, 25, 8019. https://doi.org/10.3390/ijms25158019
Corken A, Wahl EC, Sikes JD, Thakali KM. Western Diet Modifies Platelet Activation Profiles in Male Mice. International Journal of Molecular Sciences. 2024; 25(15):8019. https://doi.org/10.3390/ijms25158019
Chicago/Turabian StyleCorken, Adam, Elizabeth C. Wahl, James D. Sikes, and Keshari M. Thakali. 2024. "Western Diet Modifies Platelet Activation Profiles in Male Mice" International Journal of Molecular Sciences 25, no. 15: 8019. https://doi.org/10.3390/ijms25158019