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Review

Different Types of Cell Death in Diabetic Neuropathy: A Focus on Mechanisms and Therapeutic Strategies

1
Department of Clinical Medicine, School of Queen Mary, Jiangxi Medical College, Nanchang University, Nanchang 330031, China
2
Department of Physiology, School of Basic Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330031, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(15), 8126; https://doi.org/10.3390/ijms25158126
Submission received: 23 June 2024 / Revised: 20 July 2024 / Accepted: 24 July 2024 / Published: 25 July 2024
(This article belongs to the Section Molecular Endocrinology and Metabolism)

Abstract

Diabetic neuropathy (DN) is a common complication of diabetes, affecting over 50% of patients, leading to significant pain and a burden. Currently, there are no effective treatments available. Cell death is considered a key factor in promoting the progression of DN. This article reviews how cell death is initiated in DN, emphasizing the critical roles of oxidative stress, mitochondrial dysfunction, inflammation, endoplasmic reticulum stress, and autophagy. Additionally, we thoroughly summarize the mechanisms of cell death that may be involved in the pathogenesis of DN, including apoptosis, autophagy, pyroptosis, and ferroptosis, among others, as well as potential therapeutic targets offered by these death mechanisms. This provides potential pathways for the prevention and treatment of diabetic neuropathy in the future.
Keywords: diabetic neuropathy; cell death; apoptosis; autophagy; pyroptosis; ferroptosis diabetic neuropathy; cell death; apoptosis; autophagy; pyroptosis; ferroptosis

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MDPI and ACS Style

Ye, S.; Cheng, Z.; Zhuo, D.; Liu, S. Different Types of Cell Death in Diabetic Neuropathy: A Focus on Mechanisms and Therapeutic Strategies. Int. J. Mol. Sci. 2024, 25, 8126. https://doi.org/10.3390/ijms25158126

AMA Style

Ye S, Cheng Z, Zhuo D, Liu S. Different Types of Cell Death in Diabetic Neuropathy: A Focus on Mechanisms and Therapeutic Strategies. International Journal of Molecular Sciences. 2024; 25(15):8126. https://doi.org/10.3390/ijms25158126

Chicago/Turabian Style

Ye, Shang, Zilin Cheng, Dongye Zhuo, and Shuangmei Liu. 2024. "Different Types of Cell Death in Diabetic Neuropathy: A Focus on Mechanisms and Therapeutic Strategies" International Journal of Molecular Sciences 25, no. 15: 8126. https://doi.org/10.3390/ijms25158126

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