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Volume 25
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Review

The Possible Effects of Galectin-3 on Mechanisms of Renal and Hepatocellular Injury Induced by Intravascular Hemolysis

by
Mirjana Grujcic
1,
Marija Milovanovic
2,3,
Jelena Nedeljkovic
4,
Danijela Jovanovic
5,
Dragana Arsenijevic
2,6,
Natalija Solovjova
7,
Vesna Stankovic
2,8,
Irena Tanaskovic
2,9,
Aleksandar Arsenijevic
2,3 and
Jelena Milovanovic
2,9,*
1
Institute for Transfusiology and Hemobiology of Military Medical Academy, 11000 Belgrade, Serbia
2
Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia
3
Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia
4
Department of Medical Statistics and Informatics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
5
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
6
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
7
Academy of Applied Studies Belgrade, The College of Health Science, Cara Dušana 254, 11080 Belgrade, Serbia
8
Department of Pathology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
9
Department of Histology and Embriology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(15), 8129; https://doi.org/10.3390/ijms25158129
Submission received: 5 June 2024 / Revised: 20 July 2024 / Accepted: 23 July 2024 / Published: 25 July 2024
(This article belongs to the Special Issue Galectins (Gals))
Versions Notes

Abstract

Intravascular hemolysis is a central feature of congenital and acquired hemolytic anemias, complement disorders, infectious diseases, and toxemias. Massive and/or chronic hemolysis is followed by the induction of inflammation, very often with severe damage of organs, which enhances the morbidity and mortality of hemolytic diseases. Galectin-3 (Gal-3) is a β-galactoside-binding lectin that modulates the functions of many immune cells, thus affecting inflammatory processes. Gal-3 is also one of the main regulators of fibrosis. The role of Gal-3 in the development of different kidney and liver diseases and the potential of therapeutic Gal-3 inhibition have been demonstrated. Therefore, the objective of this review is to discuss the possible effects of Gal-3 on the process of kidney and liver damage induced by intravascular hemolysis, as well as to shed light on the potential therapeutic targeting of Gal-3 in intravascular hemolysis.
Keywords: galectin-3; intravascular hemolysis; kidney damage; liver damage galectin-3; intravascular hemolysis; kidney damage; liver damage

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MDPI and ACS Style

Grujcic, M.; Milovanovic, M.; Nedeljkovic, J.; Jovanovic, D.; Arsenijevic, D.; Solovjova, N.; Stankovic, V.; Tanaskovic, I.; Arsenijevic, A.; Milovanovic, J. The Possible Effects of Galectin-3 on Mechanisms of Renal and Hepatocellular Injury Induced by Intravascular Hemolysis. Int. J. Mol. Sci. 2024, 25, 8129. https://doi.org/10.3390/ijms25158129

AMA Style

Grujcic M, Milovanovic M, Nedeljkovic J, Jovanovic D, Arsenijevic D, Solovjova N, Stankovic V, Tanaskovic I, Arsenijevic A, Milovanovic J. The Possible Effects of Galectin-3 on Mechanisms of Renal and Hepatocellular Injury Induced by Intravascular Hemolysis. International Journal of Molecular Sciences. 2024; 25(15):8129. https://doi.org/10.3390/ijms25158129

Chicago/Turabian Style

Grujcic, Mirjana, Marija Milovanovic, Jelena Nedeljkovic, Danijela Jovanovic, Dragana Arsenijevic, Natalija Solovjova, Vesna Stankovic, Irena Tanaskovic, Aleksandar Arsenijevic, and Jelena Milovanovic. 2024. "The Possible Effects of Galectin-3 on Mechanisms of Renal and Hepatocellular Injury Induced by Intravascular Hemolysis" International Journal of Molecular Sciences 25, no. 15: 8129. https://doi.org/10.3390/ijms25158129

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