Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
Abstract
:1. Introduction
2. Results
2.1. Temporal Study of the WT Mice
2.2. Temporal Study of the APPNL-F/NL-F Model
2.3. Comparative Study Comparing the WT and the APPNL-F/NL-F at Different Time Points
2.3.1. RNFL + GCL Complex
2.3.2. IPL
2.3.3. INL
2.3.4. OPL
2.3.5. ONL
3. Discussion
4. Materials and Methods
4.1. Animals Models and Ethics
4.2. Optical Coherence Tomography
4.3. Statistical Analysis
4.4. Colorimetric Representation
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sánchez-Puebla, L.; de Hoz, R.; Salobrar-García, E.; Arias-Vázquez, A.; González-Jiménez, M.; Ramírez, A.I.; Fernández-Albarral, J.A.; Matamoros, J.A.; Elvira-Hurtado, L.; Saido, T.C.; et al. Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease. Int. J. Mol. Sci. 2024, 25, 8221. https://doi.org/10.3390/ijms25158221
Sánchez-Puebla L, de Hoz R, Salobrar-García E, Arias-Vázquez A, González-Jiménez M, Ramírez AI, Fernández-Albarral JA, Matamoros JA, Elvira-Hurtado L, Saido TC, et al. Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease. International Journal of Molecular Sciences. 2024; 25(15):8221. https://doi.org/10.3390/ijms25158221
Chicago/Turabian StyleSánchez-Puebla, Lidia, Rosa de Hoz, Elena Salobrar-García, Alberto Arias-Vázquez, María González-Jiménez, Ana I. Ramírez, José A. Fernández-Albarral, José A. Matamoros, Lorena Elvira-Hurtado, Takaomi C. Saido, and et al. 2024. "Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease" International Journal of Molecular Sciences 25, no. 15: 8221. https://doi.org/10.3390/ijms25158221