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Open AccessReview
Study of microRNAs in Gingival Crevicular Fluid as Periodontal Diseases Biomarkers: Systematic Review
by
María Cosín-Villanueva
María Cosín-Villanueva 1,
Pedro J. Almiñana-Pastor
Pedro J. Almiñana-Pastor 1,*
,
Jose Luis García-Giménez
Jose Luis García-Giménez
Jose Luis García-Giménez holds a scientific position in the Center for
Biomedical Network Research [...]
Jose Luis García-Giménez holds a scientific position in the Center for
Biomedical Network Research (CIBER-ISCIII) in the thematic area of Rare
Diseases and he is a professor of the Master in Physiology and the
Master in Biomedical Sciences at the Faculty of Medicine of the
University of Valencia. He is also the CEO of EpiDisease S.L., a Biotech
Company focused on Epigenetic Biomarkers. He earned his Bachelor's in
Chemistry in 2002 and Bachelor's in Biochemistry in 2004. After
obtaining his Ph.D. at the University of Valencia, he worked at the
Adolf Butenandt Institute, LMU University, Munich (Germany). He is a
Member of the European Innovation Partnership EIP Health for Aging A3.
Action Group and Member of the International Rare Diseases Research
Consortium (IRDiRC).
2,3,4
and
Andrés López-Roldán
Andrés López-Roldán 1
1
Department of Stomatology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
2
Biomedical Research Institute INCLIVA, 46010 Valencia, Spain
3
Consortium Center for Biomedical Network Research on Rare Diseases, CIBERER-ISCIII, 46010 Valencia, Spain
4
Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(15), 8274; https://doi.org/10.3390/ijms25158274 (registering DOI)
Submission received: 28 June 2024
/
Revised: 19 July 2024
/
Accepted: 24 July 2024
/
Published: 29 July 2024
Abstract
Aim: The aim of this review was to identify the microRNAs (miRNAs) present in gingival crevicular fluid (GCF) that can be used as biomarkers for the diagnosis of periodontal diseases, and to determine which of them has a higher diagnostic yield for periodontitis. Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines (reference number CRD42024544648). The Pubmed, Scopus, Cochrane Library, Embase, Web of Science, and Google Scholar databases were searched for clinical studies conducted in humans investigating periodontal diseases and miRNAs in GCF. The methodological quality of the articles was measured with the Newcastle–Ottawa Scale. Results: A total of 3222 references were identified in the initial literature search, and 16 articles were finally included in the review. The design of the studies was heterogeneous, which prevented a meta-analysis of the data. Most of the studies compared miRNA expression levels between patients with periodontitis and healthy controls. The most widely researched miRNA in periodontal diseases was miR-200b-3p and miR-146a. Conclusions: the miRNAs most studied are miR-146a, miR-200b, miR-223, miR-23a, and miR-203, and all of them except miR-203 have an acceptable diagnostic plausibility for periodontitis.
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MDPI and ACS Style
Cosín-Villanueva, M.; Almiñana-Pastor, P.J.; García-Giménez, J.L.; López-Roldán, A.
Study of microRNAs in Gingival Crevicular Fluid as Periodontal Diseases Biomarkers: Systematic Review. Int. J. Mol. Sci. 2024, 25, 8274.
https://doi.org/10.3390/ijms25158274
AMA Style
Cosín-Villanueva M, Almiñana-Pastor PJ, García-Giménez JL, López-Roldán A.
Study of microRNAs in Gingival Crevicular Fluid as Periodontal Diseases Biomarkers: Systematic Review. International Journal of Molecular Sciences. 2024; 25(15):8274.
https://doi.org/10.3390/ijms25158274
Chicago/Turabian Style
Cosín-Villanueva, María, Pedro J. Almiñana-Pastor, Jose Luis García-Giménez, and Andrés López-Roldán.
2024. "Study of microRNAs in Gingival Crevicular Fluid as Periodontal Diseases Biomarkers: Systematic Review" International Journal of Molecular Sciences 25, no. 15: 8274.
https://doi.org/10.3390/ijms25158274
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