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Open AccessArticle
Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals
by
Fuminari Akiyama
Fuminari Akiyama 1,†,
Natsumi Takahashi
Natsumi Takahashi 2,†,
Yuto Ueda
Yuto Ueda 1,
Shizuno Tada
Shizuno Tada 1,
Nobuyuki Takeuchi
Nobuyuki Takeuchi 1,
Yusuke Ohno
Yusuke Ohno 2,‡
and
Akio Kihara
Akio Kihara 2,*
1
Taisho Pharmaceutical Co., Ltd., 3-24-1 Takada, Toshima-ku, Tokyo 170-8633, Japan
2
Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-chome, Kita-ku, Sapporo 060-0812, Japan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Current address: Laboratory of Biochemistry, Faculty of Pharmacy, Juntendo University, Hinode-6-8-1,
Urayasu 279-0013, Japan
Int. J. Mol. Sci. 2024, 25(15), 8291; https://doi.org/10.3390/ijms25158291 (registering DOI)
Submission received: 23 June 2024
/
Revised: 21 July 2024
/
Accepted: 21 July 2024
/
Published: 29 July 2024
Abstract
Ceramides are essential lipids for skin barrier function, and various classes and species exist in the human stratum corneum (SC). To date, the relationship between skin conditions and ceramide composition in healthy individuals has remained largely unclear. In the present study, we measured six skin condition parameters (capacitance, transepidermal water loss, scaliness, roughness, multilayer exfoliation, and corneocyte cell size) for the SC of the cheeks and upper arms of 26 healthy individuals and performed correlation analyses with their SC ceramide profiles, which we measured via liquid chromatography–tandem mass spectrometry. In the cheeks, high levels and/or ratios of two free ceramide classes containing an extra hydroxyl group in the long-chain moiety and a protein-bound ceramide class containing 6-hydroxysphingosine correlated with healthy skin conditions. In contrast, the ratios of two other free ceramide classes, both containing sphingosine, and a protein-bound ceramide class containing 4,14-sphingadiene correlated with unhealthy skin conditions, as did shortening of the carbon chain of the fatty acid portion of two ceramide classes containing non-hydroxy fatty acids. Thus, our findings help to elucidate the relationship between skin conditions and ceramide composition.
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MDPI and ACS Style
Akiyama, F.; Takahashi, N.; Ueda, Y.; Tada, S.; Takeuchi, N.; Ohno, Y.; Kihara, A.
Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals. Int. J. Mol. Sci. 2024, 25, 8291.
https://doi.org/10.3390/ijms25158291
AMA Style
Akiyama F, Takahashi N, Ueda Y, Tada S, Takeuchi N, Ohno Y, Kihara A.
Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals. International Journal of Molecular Sciences. 2024; 25(15):8291.
https://doi.org/10.3390/ijms25158291
Chicago/Turabian Style
Akiyama, Fuminari, Natsumi Takahashi, Yuto Ueda, Shizuno Tada, Nobuyuki Takeuchi, Yusuke Ohno, and Akio Kihara.
2024. "Correlations between Skin Condition Parameters and Ceramide Profiles in the Stratum Corneum of Healthy Individuals" International Journal of Molecular Sciences 25, no. 15: 8291.
https://doi.org/10.3390/ijms25158291
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