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Open AccessReview
Development and Prospects of Furin Inhibitors for Therapeutic Applications
by
Alexandre V. Ivachtchenko
Alexandre V. Ivachtchenko *,
Alexander V. Khvat
Alexander V. Khvat and
Dmitrii O. Shkil
Dmitrii O. Shkil
ChemDiv Inc., San Diego, CA 92130, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(17), 9199; https://doi.org/10.3390/ijms25179199 (registering DOI)
Submission received: 22 July 2024
/
Revised: 17 August 2024
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Accepted: 22 August 2024
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Published: 24 August 2024
Abstract
Furin, a serine protease enzyme located in the Golgi apparatus of animal cells, plays a crucial role in cleaving precursor proteins into their mature, active forms. It is ubiquitously expressed across various tissues, including the brain, lungs, gastrointestinal tract, liver, pancreas, and reproductive organs. Since its discovery in 1990, furin has been recognized as a significant therapeutic target, leading to the active development of furin inhibitors for potential use in antiviral, antibacterial, anticancer, and other therapeutic applications. This review provides a comprehensive overview of the progress in the development and characterization of furin inhibitors, encompassing peptides, linear and macrocyclic peptidomimetics, and non-peptide compounds, highlighting their potential in the treatment of both infectious and non-infectious diseases.
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MDPI and ACS Style
Ivachtchenko, A.V.; Khvat, A.V.; Shkil, D.O.
Development and Prospects of Furin Inhibitors for Therapeutic Applications. Int. J. Mol. Sci. 2024, 25, 9199.
https://doi.org/10.3390/ijms25179199
AMA Style
Ivachtchenko AV, Khvat AV, Shkil DO.
Development and Prospects of Furin Inhibitors for Therapeutic Applications. International Journal of Molecular Sciences. 2024; 25(17):9199.
https://doi.org/10.3390/ijms25179199
Chicago/Turabian Style
Ivachtchenko, Alexandre V., Alexander V. Khvat, and Dmitrii O. Shkil.
2024. "Development and Prospects of Furin Inhibitors for Therapeutic Applications" International Journal of Molecular Sciences 25, no. 17: 9199.
https://doi.org/10.3390/ijms25179199
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