Reactive Oxygen Species Mechanisms that Regulate Protein–Protein Interactions in Cancer
Abstract
:1. Introduction
2. Pathways
2.1. The Ras-PI3K-Akt Pathway in Pancreatic Cancer
2.2. Bcl-2-Family Proteins in Breast Cancer
2.3. E-Cadherin and β-Catenin in Colorectal Cancer
2.4. HIF-1α and p300
2.5. Effects of ROS on Protein–Protein Interactions in Pathways of Brain and Lung Cancers
2.6. Interactions between Reactive Oxygen Species (ROS) and Lipids: Implications for Protein–Protein Interactions
2.7. Mechanisms of 4-HNE’s Interactions with Proteins
2.8. Biological Implications and Oncogenic Potential of 4-HNE
2.9. Therapeutic Implications
3. Mechanisms
3.1. Direct ROS-Mediated Mechanisms
3.2. Indirect ROS-Mediated Mechanisms
3.3. ROS-Mediated Protein Complex Stability
3.4. ROS-Mediated Protein Degradation
4. Therapeutic Approaches Targeting ROS Levels and Protein–Protein Interactions in Cancer
4.1. Current Use of Antioxidant Medications and Supplements in Cancer Therapy
4.2. Variation in ROS Levels across Different Stages of Cancer
4.3. The Role of Genetic Modifiers in ROS Sensitivity and the Development of ROS-Targeting Therapeutic Agents
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Iliadis, S.; Papanikolaou, N.A. Reactive Oxygen Species Mechanisms that Regulate Protein–Protein Interactions in Cancer. Int. J. Mol. Sci. 2024, 25, 9255. https://doi.org/10.3390/ijms25179255
Iliadis S, Papanikolaou NA. Reactive Oxygen Species Mechanisms that Regulate Protein–Protein Interactions in Cancer. International Journal of Molecular Sciences. 2024; 25(17):9255. https://doi.org/10.3390/ijms25179255
Chicago/Turabian StyleIliadis, Stavros, and Nikolaos A. Papanikolaou. 2024. "Reactive Oxygen Species Mechanisms that Regulate Protein–Protein Interactions in Cancer" International Journal of Molecular Sciences 25, no. 17: 9255. https://doi.org/10.3390/ijms25179255