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Review

Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases

by
Livia Roseti
*,
Giorgia Borciani
,
Emanuela Amore
and
Brunella Grigolo
RAMSES Laboratory, Rizzoli RIT-Research, Innovation & Technology Department, Istituto di Ricerca Codivilla Putti, IRCCS Istituto Ortopedico Rizzoli, Via di Barbiano, 1/10, 40136 Bologna, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(17), 9356; https://doi.org/10.3390/ijms25179356
Submission received: 18 July 2024 / Revised: 26 August 2024 / Accepted: 27 August 2024 / Published: 29 August 2024
(This article belongs to the Special Issue Molecular and Cellular Aspects of Autoimmune and Inflammatory Rheumatic Diseases)
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Abstract

The management of rheumatic diseases has noticeably changed in recent years with the development of targeted therapeutic agents, namely, biological disease-modifying antirheumatic drugs. Identifying essential signaling pathways and factors crucial for the development and progression of these diseases remains a significant challenge. Therapy could be used to delay the onset or reduce harm. The endocannabinoid system’s presence within the synovium can be identified as a suggested target for therapeutic interventions due to its role in modulating pain, inflammation, and joint metabolism. This review brings together the most pertinent information concerning the actions of the endocannabinoid system present in inflamed synovial tissue and its interaction with phytocannabinoids and synthetic cannabinoids, which can be used from a therapeutic perspective to minimize the inflammatory and pain processes typical of osteoarthritis and rheumatoid arthritis.
Keywords: cannabinoids; osteoarthritis; rheumatoid arthritis; inflammation; synovium cannabinoids; osteoarthritis; rheumatoid arthritis; inflammation; synovium

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MDPI and ACS Style

Roseti, L.; Borciani, G.; Amore, E.; Grigolo, B. Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases. Int. J. Mol. Sci. 2024, 25, 9356. https://doi.org/10.3390/ijms25179356

AMA Style

Roseti L, Borciani G, Amore E, Grigolo B. Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases. International Journal of Molecular Sciences. 2024; 25(17):9356. https://doi.org/10.3390/ijms25179356

Chicago/Turabian Style

Roseti, Livia, Giorgia Borciani, Emanuela Amore, and Brunella Grigolo. 2024. "Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases" International Journal of Molecular Sciences 25, no. 17: 9356. https://doi.org/10.3390/ijms25179356

APA Style

Roseti, L., Borciani, G., Amore, E., & Grigolo, B. (2024). Cannabinoids in the Inflamed Synovium Can Be a Target for the Treatment of Rheumatic Diseases. International Journal of Molecular Sciences, 25(17), 9356. https://doi.org/10.3390/ijms25179356

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