Hyaluronic Acid/Platelet-Rich Plasma Mixture Improves Temporomandibular Joint Biomechanics: A Systematic Review
Abstract
:1. Introduction
2. Results
2.1. Selection
2.2. Individual Studies
2.3. Syntheses
3. Discussion
3.1. Interpretation
3.2. Limitations
3.3. Strengths
3.4. Implications
4. Materials and Methods
4.1. Protocol and Criteria
4.2. Searches
4.3. Selection and Collection
4.4. Assessments
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Appendix A
First Author | Publication Year | Digital Object Identifier or PubMed Identifier | Title | Reasons for Exclusion |
---|---|---|---|---|
Yuan [66] | 2024 | https://doi.org/10.6084/m9.figshare.25324966.v1 | Comparison of Temporomandibular Joint Osteoarthritis Treatment Efficacy of Platelet-rich Plasma and Hyaluronic Acid Injection in Upper or Lower TMJ Space | Ineligible intervention |
Liu [67] | 2023 | https://doi.org/10.1016/j.jcms.2023.09.014 | Platelet-rich plasma therapy for temporomandibular joint osteoarthritis: A randomized controlled trial | Ineligible intervention |
Shan [68] | 2023 | https://doi.org/10.57760/sciencedb.o00013.00022 | Platelet-rich plasma and hyaluronic acid for Injection treatment of temporomandibular joint degeneration | Ineligible intervention |
Vingender [69] | 2023 | https://doi.org/10.1016/j.jcms.2023.01.017 | Evaluation of the efficiency of hyaluronic acid, PRP and I-PRF intra-articular injections in the treatment of internal derangement of the temporomandibular joint: A prospective study | Ineligible intervention |
Dasukil [70] | 2022 | https://doi.org/10.1016/j.jcms.2022.10.002 | Intra-articular injection of hyaluronic acid versus platelet-rich plasma following single puncture arthrocentesis for the management of internal derangement of TMJ: A double-blinded randomized controlled trial | Ineligible intervention |
Isik [71] | 2022 | https://doi.org/10.1016/j.jcms.2022.06.006 | Injectable platelet-rich fibrin as treatment for temporomandibular joint osteoarthritis: A randomized controlled clinical trial | Ineligible intervention |
Jacob [72] | 2022 | https://doi.org/10.1007/s12663-021-01519-y | Efficacy of Platelet-Rich Plasma Versus Hyaluronic Acid Following Arthrocentesis for Temporomandibular Joint Disc Disorders: A Randomized Controlled Trial | Ineligible intervention |
Leketas [73] | 2022 | https://doi.org/10.1080/08869634.2022.2081445 | Different intra-articular injection substances following temporomandibular joint arthroscopy and their effect on early postoperative period: A randomized clinical trial | Ineligible intervention |
Macedo de Sousa [74] | 2022 | https://doi.org/10.3390/life12111739 | Medium-Term Effect of Treatment with Intra-Articular Injection of Sodium Hyaluronate, Betamethasone and Platelet-Rich Plasma in Patients with Temporomandibular Arthralgia: A Retrospective Cohort Study. | Ineligible intervention |
Ramakrishnan [75] | 2022 | https://doi.org/10.4103/njms.njms_94_20 | Comparison of intraarticular injection of platelet-rich plasma following arthrocentesis, with sodium hyaluronate and conventional arthrocentesis for management of internal derangement of temporomandibular joint. | Ineligible intervention |
De Sousa [76] | 2020 | https://doi.org/10.3390/medicina56030113 | Different treatments in patients with temporomandibular joint disorders: A comparative randomized study | Ineligible intervention |
Kim [77] | 2020 | https://doi.org/10.1186/s13063-020-04442-8 | Efficacy, safety, and economic assessment of hominis placental pharmacopuncture for chronic temporomandibular disorder: A protocol for a multicentre randomized controlled trial | Ineligible publication type (study protocol) |
Pihut [78] | 2020 | https://doi.org/10.3390/ijerph17134726 | The application of intra-articular injections for management of the consequences of disc displacement without reduction | Ineligible intervention |
Kutuk [79] | 2019 | https://doi.org/10.1097/scs.0000000000005211 | Clinical and radiological comparison of effects of platelet-rich plasma, hyaluronic acid, and corticosteroid injections on temporomandibular joint osteoarthritis | Ineligible intervention |
Martín-Granizo [80] | 2018 | https://doi.org/10.1016/j.bjoms.2018.07.004 | Simple and secure intra-articular infiltration during arthroscopy of the temporomandibular joint | Ineligible intervention |
Fernández-Ferro [81] | 2017 | https://doi.org/10.1016/j.jcms.2017.01.010 | Comparison of intra-articular injection of plasma rich in growth factors versus hyaluronic acid following arthroscopy in the treatment of temporomandibular dysfunction: A randomized prospective study | Ineligible intervention |
Hossameldin [82] | 2017 | https://doi.org/10.1016/j.ijom.2017.02.776 | Efficacy of platelet-rich plasma versus hyaluronic acid intraarticular injection in arthroscopic management of Wilkes V temporomandibular joint patients | Ineligible intervention |
Pihut [83] | 2017 | PMID: 29263455 | Evaluation of remission of temporomandibular joints pain as a result of treatment of dysfunction using intra-articular injection | Ineligible intervention |
Cömert Kiliç [84] | 2016 | https://doi.org/10.1016/j.ijom.2016.06.009 | Is arthrocentesis plus platelet-rich plasma superior to arthrocentesis plus hyaluronic acid for the treatment of temporomandibular joint osteoarthritis: A randomized clinical trial | Ineligible intervention |
Hegab [85] | 2015 | https://doi.org/10.1016/j.joms.2015.03.045 | Platelet-rich plasma injection as an effective treatment for temporomandibular joint osteoarthritis | Ineligible intervention |
Machoň [86] | 2013 | https://doi.org/10.1016/j.ijom.2013.07.694 | Platelet-Rich Plasma in Temporomandibular Joint Osteoarthritis Therapy: A 3-Month Follow-Up Pilot Study | Ineligible intervention |
Kargi [87] | 2002 | https://doi.org/10.1097/00006534-200206000-00077 | Intraarticular injections of sodium hyaluronate for temporomandibular joint disorder | Ineligible intervention |
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First Author | Publication Year | Digital Object Identifier or PubMed Identifier | Title |
---|---|---|---|
Attia [39] | 2024 | https://doi.org/10.1007/s12663-023-01907-6 | Hyaluronic Acid and Platelet-Rich Plasma Mixture Versus Hyaluronic Acid and Corticosteroid in the Treatment of Temporomandibular Joint Internal Derangement: A Comparative Randomized Study |
Hegab [40] | 2023 | https://doi.org/10.1016/j.jormas.2022.11.016 | Synergistic effect of platelet rich plasma with hyaluronic acid injection following arthrocentesis to reduce pain and improve function in TMJ osteoarthritis |
Asadpour [41] | 2022 | https://doi.org/10.1016/j.joms.2022.05.002 | Combined Platelet-Rich Plasma and Hyaluronic Acid can Reduce Pain in Patients Undergoing Arthrocentesis for Temporomandibular Joint Osteoarthritis |
ElMonem Arboud [42] | 2022 | https://doi.org/10.4103/tdj.tdj_5_22 | Evaluation of intraarticular injection of hyaluronic acid with platelet rich plasma for treatment of temporomandibular joint anterior disc displacement with and without reduction |
Harba [43] | 2021 | https://doi.org/10.17219/dmp/127446 | Evaluation of the participation of hyaluronic acid with platelet-rich plasma in the treatment of temporomandibular joint disorders |
Saad [44] | 2017 | https://doi.org/10.21608/edj.2017.76108 | Intra articular injection of hyaluronic acid alone in comparison with hyaluronic acid and PRP in the treatment of internal derangement of temporomandibular joint |
First Author, Publication Year | Diagnosis | Study Group Number of Patients | Study Group Substance | Control Group Number of Patients | Control Group Substance | Follow-Up Duration |
---|---|---|---|---|---|---|
Attia, 2024 [39] | Disk displacement with reduction | 30 | HA + PRP | 30 | HA + CS | 6 months |
Hegab, 2023 [40] | TMJ osteoarthritis | 30 | AC + HA + PRP | 30 | AC + HA | 12 months |
30 | AC + PRP | |||||
Asadpour, 2022 [41] | TMJ osteoarthritis | 10 | AC + HA + PRP | 10 | AC + HA | 6 months |
10 | AC + PRP | 6 months | ||||
ElMonem Arboud, 2022 [42] | Disk displacement with reduction | 10 | AC + HA + PRP | 0 | N/A | 6 months |
Disk displacement without reduction | 10 | AC + HA + PRP | 0 | N/A | 6 months | |
Harba, 2021 [43] | Temporomandibular disorders | 12 | HA + PRP | 12 | HA | 6 months |
Saad, 2017 [44] | Disk displacement | 10 | AC + HA + PRP | 10 | AC + HA | 6 months |
First Author, Publication Year | Group, Size | Baseline | 1 Week | 2 Weeks | 3 Weeks | 1 Month | 3 Months | 6 Months | 12 Months |
---|---|---|---|---|---|---|---|---|---|
Attia, 2024 [39] | HA + PRP, 30 | 36.00 | 41.50 | N/S | N/S | N/S | 47.00 | 53.00 * | N/S |
HA + CS, 30 | 36.50 | 43.00 | N/S | N/S | N/S | 49.00 | 51.00 * | N/S | |
Mean difference | −0.50 † | −1.50 | N/S | N/S | N/S | −2.00 | 2.00 † | N/S | |
Hegab, 2023 [40] | AC + HA + PRP, 30 | 25.40 SD = 3.10 | N/S | N/S | N/S | 36.90 SD = 3.20 | 40.00 SD = 2.70 | 41.23 * SD = 2.50 | 41.90 SD = 2.20 |
AC + HA, 30 | 25.80 SD = 3.20 | N/S | N/S | N/S | 36.30 SD = 2.20 | 39.10 SD = 1.80 | 40.70 * SD = 2.06 | 39.10 SD = 2.80 | |
Mean difference | −0.40 † SE = 0.81 | N/S | N/S | N/S | 0.60 † SE = 0.71 | 0.90 † SE = 0.59 | 0.53 † SE = 0.59 | 2.80 * SE = 0.65 | |
AC + PRP, 30 | 27.10 SD = 2.90 | N/S | N/S | N/S | 34.30 SD = 2.80 | 37.30 SD = 2.30 | 38.60 * SD = 1.50 | 41.40 SD = 2.70 | |
Mean difference | −1.70 * SE = 0.78 | N/S | N/S | N/S | 2.60 * SE = 0.78 | 2.70 * SE = 0.65 | 2.63 * SE = 0.53 | 0.50 † SE = 0.64 | |
Asadpour, 2022 [41] | AC + HA + PRP, 10 | 23.10 SD = 2.40 | N/S | N/S | N/S | 33.70 SD = 1.70 | N/S | 33.20 * SD = 1.60 | N/S |
AC + HA, 10 | 23.00 SD = 2.30 | N/S | N/S | N/S | 31.70 SD = 1.60 | N/S | 31.00 * SD = 1.60 | N/S | |
Mean difference | 0.10 † SE = 1.05 | N/S | N/S | N/S | 2.00 * SE = 0.74 | N/S | 2.20 * SE = 0.72 | N/S | |
AC + PRP, 10 | 23.30 SD = 2.50 | N/S | N/S | N/S | 32.60 SD = 1.70 | N/S | 31.50 * SD = 1.50 | N/S | |
Mean difference | −0.20 † SE = 1.10 | N/S | N/S | N/S | 1.10 † SE = 0.76 | N/S | 1.70 * SE = 0.69 | N/S | |
ElMonem Arboud, 2022 [42] | AC + HA + PRP DDwR, 10 | 32.40 SD = 1.96 | 34.00 | 38.00 | 39.00 | 42.00 | 44.00 | 44.90 * SD = 1.20 | N/S |
AC + HA + PRP DDwoR, 10 | 24.00 SD = 6.50 | 25.00 | 27.00 | 29.00 | 31.00 | 34.00 | 34.66 * SD = 10.59 | N/S | |
Harba, 2021 [43] | HA + PRP, 12 | 34.71 SD = 9.42 | N/S | 43.58 SD = 5.52 | N/S | 43.92 SD = 6.78 | 43.04 SD = 7.26 | 42.88 * SD = 7.16 | N/S |
HA, 12 | 35.08 SD = 10.54 | N/S | 40.88 SD = 7.14 | N/S | 41.75 SD = 6.09 | 39.67 SD = 5.05 | 39.08 † SD = 6.31 | N/S | |
Mean difference | −0.37 † | N/S | 2.70 † SE = 2.61 | N/S | 2.17 † SE = 2.63 | 3.37 † SE = 2.55 | 3.80 † SE = 2.76 | N/S | |
Saad, 2017 [44] | AC + HA + PRP, 10 | 28.40 SD = 2.07 | 35.90 SD = 2.42 | 36.50 SD = 1.65 | 38.90 SD = 1.52 | 39.90 SD = 1.52 | 40.60 SD = 1.52 | 40.70 * SD = 1.42 ‡ | N/S |
AC + HA, 10 | 25.70 SD = 3.50 | 31.30 SD = 2.75 | 33.10 SD = 2.28 | 34.90 SD = 1.52 | 36.95 SD = 1.42 | 39.30 SD = 3.54 | 42.40 * SD = 3.44 | N/S | |
Mean difference | 2.70 † SE = 1.29 | 4.60 * SE = 1.16 | 3.40 * SE = 0.89 | 4.00 * SE = 1.68 | 2.95 * SE = 0.66 | 1.30 † SE = 1.22 | −1.70 † SD = 1.18 | N/S |
First Author, Publication Year | Group, Size | Baseline | 1 Week | 2 Weeks | 3 Weeks | 1 Month | 3 Months | 6 Months | 12 Months |
---|---|---|---|---|---|---|---|---|---|
Attia, 2024 [39] | HA + PRP, 30 | 8.00 | 7.00 | N/S | N/S | N/S | 2.00 | 0.00 * | N/S |
HA + CS, 30 | 8.00 | 5.00 | N/S | N/S | N/S | 3.00 | 2.00 * | N/S | |
Mean difference | 0.00 † | 2.00 | N/S | N/S | N/S | −1.00 | −2.00 * | N/S | |
Hegab, 2023 [40] | AC + HA + PRP, 30 | 7.70 SD = 0.90 | N/S | N/S | N/S | 2.03 SD = 0.80 | 0.20 SD = 0.40 | 0.00 * SD = 0.00 | 0.00 SD = 0.00 |
AC + HA, 30 | 7.20 SD = 1.40 | N/S | N/S | N/S | 2.90 SD = 0.90 | 0.30 SD = 0.50 | 0.30 * SD = 0.55 | 1.70 SD = 1.40 | |
Mean difference | 0.50 † SE = 0.30 | N/S | N/S | N/S | −0.87 * SE = 0.22 | −0.10 † SE = 0.12 | −0.30 * SE = 0.10 | −1.70 * SE = 0.26 | |
AC + PRP, 30 | 7.40 SD = 1.10 | N/S | N/S | N/S | 7.10 SD = 1.20 | 4.10 SD = 1.06 | 1.60 * SD = 0.80 | 0.40 SD = 0.70 | |
Mean difference | 0.30 † SE = 0.26 | N/S | N/S | N/S | −5.07 * SD = 0.26 | −3.90 * SD = 0.21 | −1.60 * SE = 0.15 | −0.40 * SE = 0.13 | |
Asadpour, 2022 [41] | AC + HA + PRP, 10 | 7.10 SD = 0.50 | N/S | N/S | N/S | 1.60 SD = 0.50 | N/S | 2.00 * SD = 0.80 | N/S |
AC + HA, 10 | 7.10 SD = 0.80 | N/S | N/S | N/S | 2.30 SD = 0.70 | N/S | 3.00 * SD = 0.80 | N/S | |
Mean difference | 0.00 † SE = 0.30 | N/S | N/S | N/S | −0.70 * SE = 0.27 | N/S | −1.00 * SE = 0.36 | N/S | |
AC + PRP, 10 | 7.00 SD = 0.70 | N/S | N/S | N/S | 2.20 SD = 0.60 | N/S | 3.00 * SD = 1.20 | N/S | |
Mean difference | 0.10 † SE = 0.27 | N/S | N/S | N/S | −0.60 * SE = 0.25 | N/S | −1.00 * SE = 0.46 | N/S | |
ElMonem Arboud, 2022 [42] | AC + HA + PRP DDwR, 10 | 6.90 SD = 0.99 | N/S | N/S | N/S | N/S | N/S | 0.60 * SD = 0.52 | N/S |
AC + HA + PRP DDwoR, 10 | 6.80 SD = 1.04 | N/S | N/S | N/S | N/S | N/S | 0.80 * SD = 0.79 | N/S | |
Harba, 2021 [43] | HA + PRP, 12 | 6.75 SD = 2.46 | N/S | 3.25 SD = 1.02 | N/S | 2.58 SD = 1.88 | 2.38 SD = 2.09 | 2.25 * SD = 2.11 | N/S |
HA, 12 | 6.50 SD = 1.65 | N/S | 4.48 SD = 1.57 | N/S | 3.31 SD = 1.72 | 2.75 SD = 1.22 | 3.50 * SD = 1.35 | N/S | |
Mean difference | 2.25 † SE = 0.86 | N/S | −1.23 * SD = 0.54 | N/S | −0.73 † SD = 0.74 | −0.37 † SD = 0.70 | −1.25 † SE = 0.72 | N/S | |
Saad, 2017 [44] | AC + HA + PRP, 10 | 6.70 SD = 1.34 | 3.50 SD = 0.71 | 1.60 SD = 0.70 | 0.95 SD = 0.44 | 0.85 SD = 0.47 | 0.50 SD = 0.53 | 0.67 * SD = 0.53 | N/S |
AC + HA, 10 | 6.90 SD = 1.20 | 4.40 SD = 0.97 | 1.20 SD = 0.79 | 0.51 SD = 0.71 | 0.75 SD = 0.69 | 0.60 SD = 0.43 | 0.69 * SD = 0.51 | N/S | |
Mean difference | −0.20 † SE = 0.57 | −0.90 * SD = 0.38 | 0.40 † SD = 0.33 | 0.44 † SD = 0.26 | 0.10 † SD = 0.26 | −0.10 † SD = 0.22 | −0.02 † SE = 0.23 | N/S |
Comparison | Number of Studies and Study/Control Groups | Total Number of Subjects in Study/Control Groups | Mean Difference with Standard Error, Statistical Significance and Confidence Interval | Effect Size with Standard Error and 95% Confidence Interval |
---|---|---|---|---|
Mandibular abduction in HA + PRP versus HA treatment | 6 7/4 | 112/62 | 1.47 SE = 2.68; p = 0.60 −4.59–7.53 | 0.34 SE = 0.63 −0.89–1.58 |
Mandibular abduction in HA + PRP versus PRP treatment | 6 7/2 | 112/40 | 2.52 SE = 2.44; p = 0.34 −3.24–8.28 | 0.83 SE = 0.83 −0.79–2.45 |
Articular pain in HA + PRP versus HA treatment | 6 7/4 | 112/62 | −1.18 SE = 0.92; p = 0.23 −3.27–0.91 | −0.80 SE = 0.65 −2.07–0.47 |
Articular pain in HA + PRP versus PRP treatment | 6 7/2 | 112/40 | −1.33 SE = 1.02; p = 0.23 −3.74–1.08 | −1.05 SE = 0.84 −2.69–0.60 |
Criteria for Inclusion | Criteria for Exclusion | |
---|---|---|
Sample | Patients presenting temporomandibular joint disorders | Non-human research, cadaver research |
Phenomenon of interest | Injections of HA mixed with blood product into the temporomandibular joints | Extracapsular injections |
Design | Randomized clinical trials (applicable to meta-analysis) | Not applicable |
Evaluation | Range of mandibular abduction, temporomandibular joint pain, health-related quality of life | Descriptive results only |
Research type | Quantitative applied research | Not applicable |
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Chęciński, M.; Lubecka, K.; Bliźniak, F.; Chlubek, D.; Sikora, M. Hyaluronic Acid/Platelet-Rich Plasma Mixture Improves Temporomandibular Joint Biomechanics: A Systematic Review. Int. J. Mol. Sci. 2024, 25, 9401. https://doi.org/10.3390/ijms25179401
Chęciński M, Lubecka K, Bliźniak F, Chlubek D, Sikora M. Hyaluronic Acid/Platelet-Rich Plasma Mixture Improves Temporomandibular Joint Biomechanics: A Systematic Review. International Journal of Molecular Sciences. 2024; 25(17):9401. https://doi.org/10.3390/ijms25179401
Chicago/Turabian StyleChęciński, Maciej, Karolina Lubecka, Filip Bliźniak, Dariusz Chlubek, and Maciej Sikora. 2024. "Hyaluronic Acid/Platelet-Rich Plasma Mixture Improves Temporomandibular Joint Biomechanics: A Systematic Review" International Journal of Molecular Sciences 25, no. 17: 9401. https://doi.org/10.3390/ijms25179401