Telomere Length, HLA, and Longevity—Results from a Multicenter Study
Abstract
:1. Introduction
2. Results
2.1. Distribution of HLA Class I and II Alleles in the Studied Populations
2.2. Comparison of Telomere Length among Elderly and Young Representatives in the Studied Populations
2.3. Relationships between Telomere Length and HLA Genotype
Haplotype | HF Young (n = 122) | HF Elderly (n = 62) | OR | CI.L | CI.U | p-Value |
---|---|---|---|---|---|---|
A*02~B*35~DRB1*16 | 0 | 0.0323 | 18.26 | 0.98 | 341.97 | 0.005 |
A*02~B*49~DRB1*14 | 0 | 0.0242 | 14.09 | 0.72 | 274.91 | 0.015 |
A*02~B*51~DRB1*10 | 0 | 0.0161 | 9.98 | 0.48 | 209.50 | 0.047 |
A*02~B*57~DRB1*07 | 0 | 0.0161 | 9.98 | 0.48 | 209.50 | 0.047 |
A*24~B*40~DRB1*03 | 0 | 0.0161 | 9.98 | 0.48 | 209.50 | 0.047 |
A*01~DRB1*11 | 0.0451 | 0.1048 | 2.48 | 0.99 | 6.31 | 0.030 |
A*02~DRB1*10 | 0.0041 | 0.0323 | 8.10 | 0.90 | 73.27 | 0.030 |
B*35~DRB1*07 | 0.0041 | 0.0323 | 8.10 | 0.90 | 73.27 | 0.030 |
C*08~DRB1*01 | 0.0410 | 0 | 0.09 | 0.01 | 1.54 | 0.020 |
DRB1*04~DQB1*04 | 0 | 0.0242 | 14.09 | 0.72 | 274.91 | 0.015 |
DRB1*07~DQB1*03 | 0.0041 | 0.0323 | 8.10 | 0.90 | 73.27 | 0.030 |
Haplotype | HF Young (n = 100) | HF Elderly (n = 100) | OR | CI.L | CI.U | p-Value |
---|---|---|---|---|---|---|
A*02~DRB1*12 | 0.03 | 0 | 0.07 | 0.00 | 1.33 | 0.030 |
A*03~DRB1*01 | 0.005 | 0.04 | 8.29 | 1.03 | 66.93 | 0.040 |
A*01~B*08 | 0.02 | 0.07 | 3.69 | 1.13 | 15.62 | 0.016 |
A*02~B*35 | 0.075 | 0.03 | 0.38 | 0.12 | 1.07 | 0.040 |
A*02~C*07 | 0.14 | 0.07 | 0.46 | 0.22 | 0.95 | 0.020 |
A*68~C*07 | 0 | 0.04 | 17.71 | 1.01 | 308.89 | 0.007 |
DRB1*04~DQB1*03 | 0.125 | 0.065 | 0.49 | 0.22 | 1.03 | 0.040 |
DRB1*04~DQA1*03~DQB1*03 | 0.125 | 0.055 | 0.41 | 0.18 | 0.89 | 0.010 |
DRB1*14~DQA1*01~DQB1*05 | 0.025 | 0.065 | 2.71 | 0.88 | 9.88 | 0.054 |
A*01~B*08~DRB1*03 | 0.015 | 0.055 | 3.82 | 0.99 | 21.6 | 0.030 |
Haplotype | HF Young (n = 158) | HF Elderly (n = 122) | OR | CI.L | CI.U | p-Value |
---|---|---|---|---|---|---|
A*02~C*05 | 0.0095 | 0.0410 | 4.46 | 1.13 | 25.42 | 0.010 |
B*15~C*03 | 0.0253 | 0 | 0.07 | 0.00 | 1.29 | 0.010 |
A*01~DRB1*11 | 0.0253 | 0.0041 | 0.16 | 0.02 | 1.28 | 0.048 |
A*02~DRB1*03 | 0.0158 | 0.0492 | 3.22 | 1.04 | 11.8 | 0.020 |
A*26~DRB1*04 | 0.0190 | 0 | 0.10 | 0.01 | 1.74 | 0.040 |
A*26~DRB1*07 | 0 | 0.0164 | 11.84 | 0.63 | 221.06 | 0.040 |
A*03~DRB1*03 | 0 | 0.0164 | 11.84 | 0.63 | 221.06 | 0.040 |
B*07~DRB1*15 | 0.0285 | 0.0041 | 0.14 | 0.02 | 1.12 | 0.030 |
B*51~DRB1*15 | 0.0285 | 0.0041 | 0.14 | 0.02 | 1.12 | 0.030 |
B*44~DRB1*15 | 0.0190 | 0 | 0.10 | 0.005 | 1.74 | 0.040 |
C*04~DRB1*04 | 0.0411 | 0.0082 | 0.19 | 0.02 | 0.87 | 0.020 |
C*04~DRB1*11 | 0.0222 | 0.0574 | 2.69 | 0.99 | 7.98 | 0.030 |
DRB1*10~DQB1*05 | 0.0380 | 0.0082 | 0.21 | 0.05 | 0.94 | 0.025 |
DRB1*15~DQB1*05 | 0.0285 | 0.0000 | 0.07 | 0.004 | 1.14 | 0.008 |
A*03~B*35~DRB1*03 | 0 | 0.0164 | 11.84 | 0.63 | 221.06 | 0.040 |
3. Discussion
4. Materials and Methods
4.1. Subjects
4.2. Quantification of Telomere Length
4.3. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Elderly Individuals | Young Individuals | |
---|---|---|
Bulgaria | N = 68 | N = 121 |
Male, n (%) | 24 (35%) | 43 (36%) |
Female, n (%) | 44 (65%) | 78 (64%) |
Mean age (years ± SD) | 71 ± 6.19 | 27 ± 4.03 |
Romania | N = 100 | N = 100 |
Male, n (%) | 49 (49%) | 55 (55%) |
Female, n (%) | 51 (51%) | 45 (45%) |
Mean age (years ± SD) | 71 ± 5.74 | 30 ± 3.40 |
Turkey | N = 125 | N = 80 |
Male, n (%) | 38 (30%) | 38 (48%) |
Female, n (%) | 87 (70%) | 42 (52%) |
Mean age (years ± SD) | 85 ± 6.99 | 37.79 ± 6.44 |
Poland | N = 99 | N = 264 |
Male, n (%) | 37 (37%) | 134 (51%) |
Female, n (%) | 62 (63%) | 130 (49%) |
Mean age (years ± SD) | 74 ± 6.19 | 34 ± 9.06 |
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Dratwa-Kuzmin, M.; Hadra, B.A.; Oguz, F.; Ogret, Y.; Constantinescu, I.; Apostol, D.; Talangescu, A.; Constantinescu, A.-E.; Maruntelu, I.; Kościńska, K.; et al. Telomere Length, HLA, and Longevity—Results from a Multicenter Study. Int. J. Mol. Sci. 2024, 25, 9457. https://doi.org/10.3390/ijms25179457
Dratwa-Kuzmin M, Hadra BA, Oguz F, Ogret Y, Constantinescu I, Apostol D, Talangescu A, Constantinescu A-E, Maruntelu I, Kościńska K, et al. Telomere Length, HLA, and Longevity—Results from a Multicenter Study. International Journal of Molecular Sciences. 2024; 25(17):9457. https://doi.org/10.3390/ijms25179457
Chicago/Turabian StyleDratwa-Kuzmin, Marta, Bushra Al Hadra, Fatma Oguz, Yeliz Ogret, Ileana Constantinescu, Dimitri Apostol, Adriana Talangescu, Alexandra-Elena Constantinescu, Ion Maruntelu, Katarzyna Kościńska, and et al. 2024. "Telomere Length, HLA, and Longevity—Results from a Multicenter Study" International Journal of Molecular Sciences 25, no. 17: 9457. https://doi.org/10.3390/ijms25179457