Transient Increases in Neural Oscillations and Motor Deficits in a Mouse Model of Parkinson’s Disease
Abstract
:1. Introduction
2. Results
2.1. Histological Evaluation
2.2. Results of Behavioral Tests
2.3. Dynamic Changes in LFP Power Spectra Following Dopaminergic Lesion across Resting and Walking Phases
3. Discussion
3.1. Loss of Dopaminergic Neurons in the SNc and Motor Function Impairments Resulting from 6-OHDA
3.2. Transient Changes in LFP Bands after 6-OHDA Lesion
4. Materials and Methods
4.1. Animals
4.2. Surgery
4.2.1. Unilateral 6-OHDA Lesions
4.2.2. Electrode Implantation
4.3. Behavioral Tests
4.3.1. Rotarod Test
4.3.2. Pole Test
4.3.3. Beam Traversal Test
4.3.4. Open Field Test
4.3.5. Rearing Cylinder Test
4.3.6. Gait Analysis
4.4. Electrophysiological Recordings and Data Analysis
4.5. Histology and Immunohistochemistry
4.6. Cell Counting
4.7. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Band | Factor | F | p-Value | Partial η2 | LSD |
---|---|---|---|---|---|
Delta | group(1,18) 1 | 4.516 | 0.048 | 0.201 | Lesion > Sham 2 |
channel(4,72) | 1.608 | 0.204 | 0.082 | NA 3 | |
group*channel(4,72) | 0.635 | 0.639 | 0.034 | NA | |
Theta | group(1,18) | 4.191 | 0.056 | 0.189 | Lesion > Sham |
channel(4,72) | 3.016 | 0.048 | 0.144 | PPN/SNc/STN > CPu | |
group*channel(4,72) | 0.420 | 0.794 | 0.023 | NA | |
Alpha | group(1,18) | 3.999 | 0.061 | 0.182 | Lesion > Sham |
channel(4,72) | 3.457 | 0.050 | 0.161 | PPN > CPu/M1 | |
group*channel(4,72) | 0.095 | 0.984 | 0.005 | NA | |
Beta | group(1,18) | 4.425 | 0.050 | 0.197 | Lesion > Sham |
channel(4,72) | 6.491 | 0.001 | 0.265 | PPN/SNc/STN > M1; CPu > M1; STN > CPu | |
group*channel(4,72) | 0.708 | 0.589 | 0.038 | NA | |
Gamma | group(1,18) | 5.804 | 0.027 | 0.244 | Lesion > Sham |
channel(4,72) | 3.616 | 0.023 | 0.167 | PPN/SNc/STN > M1 | |
group*channel(4,72) | 0.432 | 0.785 | 0.023 | NA |
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Wu, Y.; Lu, L.; Qing, T.; Shi, S.; Fang, G. Transient Increases in Neural Oscillations and Motor Deficits in a Mouse Model of Parkinson’s Disease. Int. J. Mol. Sci. 2024, 25, 9545. https://doi.org/10.3390/ijms25179545
Wu Y, Lu L, Qing T, Shi S, Fang G. Transient Increases in Neural Oscillations and Motor Deficits in a Mouse Model of Parkinson’s Disease. International Journal of Molecular Sciences. 2024; 25(17):9545. https://doi.org/10.3390/ijms25179545
Chicago/Turabian StyleWu, Yue, Lidi Lu, Tao Qing, Suxin Shi, and Guangzhan Fang. 2024. "Transient Increases in Neural Oscillations and Motor Deficits in a Mouse Model of Parkinson’s Disease" International Journal of Molecular Sciences 25, no. 17: 9545. https://doi.org/10.3390/ijms25179545