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Review

O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer

by
Itzel Patricia Vásquez Martínez
1,†,
Eduardo Pérez-Campos
2,†,
Laura Pérez-Campos Mayoral
1,
Holanda Isabel Cruz Luis
1,
María del Socorro Pina Canseco
1,
Edgar Zenteno
3,
Irma Leticia Bazán Salinas
1,
Margarito Martínez Cruz
2,
Eduardo Pérez-Campos Mayoral
1 and
María Teresa Hernández-Huerta
4,*
1
UNAM-UABJO Faculty of Medicine Research Center, Faculty of Medicine and Surgery, Autonomous University “Benito Juarez” of Oaxaca, Oaxaca 68020, Mexico
2
National Institute of Technology of Mexico, Technological Institute of Oaxaca, Oaxaca 68033, Mexico
3
Department of Biochemistry, Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico
4
National Council of Humanities, Sciences and Technologies (CONAHCYT), Faculty of Medicine and Surgery, Autonomous University “Benito Juarez” of Oaxaca, Oaxaca 68120, Mexico
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(18), 9896; https://doi.org/10.3390/ijms25189896
Submission received: 2 August 2024 / Revised: 3 September 2024 / Accepted: 10 September 2024 / Published: 13 September 2024
(This article belongs to the Topic Cancer Cell Metabolism (2nd Edition))
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Abstract

O-linked β-N-acetylglucosamine (O-GlcNAc, O-GlcNAcylation) is a post-translational modification of serine/threonine residues of proteins. Alterations in O-GlcNAcylation have been implicated in several types of cancer, regulation of tumor progression, inflammation, and thrombosis through its interaction with signaling pathways. We aim to explore the relationship between O-GlcNAcylation and hemostasis, inflammation, and cancer, which could serve as potential prognostic tools or clinical predictions for cancer patients’ healthcare and as an approach to combat cancer. We found that cancer is characterized by high glucose demand and consumption, a chronic inflammatory state, a state of hypercoagulability, and platelet hyperaggregability that favors thrombosis; the latter is a major cause of death in these patients. Furthermore, we review transcription factors and pathways associated with O-GlcNAcylation, thrombosis, inflammation, and cancer, such as the PI3K/Akt/c-Myc pathway, the nuclear factor kappa B pathway, and the PI3K/AKT/mTOR pathway. We also review infectious agents associated with cancer and chronic inflammation and potential inhibitors of cancer cell development. We conclude that it is necessary to approach both the diagnosis and treatment of cancer as a network in which multiple signaling pathways are integrated, and to search for a combination of potential drugs that regulate this signaling network.
Keywords: O-GlcNAc; hemostasis; inflammation; cancer; post-translational modification O-GlcNAc; hemostasis; inflammation; cancer; post-translational modification

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MDPI and ACS Style

Vásquez Martínez, I.P.; Pérez-Campos, E.; Pérez-Campos Mayoral, L.; Cruz Luis, H.I.; Pina Canseco, M.d.S.; Zenteno, E.; Bazán Salinas, I.L.; Martínez Cruz, M.; Pérez-Campos Mayoral, E.; Hernández-Huerta, M.T. O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer. Int. J. Mol. Sci. 2024, 25, 9896. https://doi.org/10.3390/ijms25189896

AMA Style

Vásquez Martínez IP, Pérez-Campos E, Pérez-Campos Mayoral L, Cruz Luis HI, Pina Canseco MdS, Zenteno E, Bazán Salinas IL, Martínez Cruz M, Pérez-Campos Mayoral E, Hernández-Huerta MT. O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer. International Journal of Molecular Sciences. 2024; 25(18):9896. https://doi.org/10.3390/ijms25189896

Chicago/Turabian Style

Vásquez Martínez, Itzel Patricia, Eduardo Pérez-Campos, Laura Pérez-Campos Mayoral, Holanda Isabel Cruz Luis, María del Socorro Pina Canseco, Edgar Zenteno, Irma Leticia Bazán Salinas, Margarito Martínez Cruz, Eduardo Pérez-Campos Mayoral, and María Teresa Hernández-Huerta. 2024. "O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer" International Journal of Molecular Sciences 25, no. 18: 9896. https://doi.org/10.3390/ijms25189896

APA Style

Vásquez Martínez, I. P., Pérez-Campos, E., Pérez-Campos Mayoral, L., Cruz Luis, H. I., Pina Canseco, M. d. S., Zenteno, E., Bazán Salinas, I. L., Martínez Cruz, M., Pérez-Campos Mayoral, E., & Hernández-Huerta, M. T. (2024). O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer. International Journal of Molecular Sciences, 25(18), 9896. https://doi.org/10.3390/ijms25189896

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