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Volume 25
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10.3390/ijms251910326
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Review

Harnessing B7-H6 for Anticancer Immunotherapy: Expression, Pathways, and Therapeutic Strategies

by
Sunyoung Lee
1,2,
Ji Hyun Kim
1,3,
In-Hwan Jang
1,
Seona Jo
1,3,
Soo Yun Lee
1,
Se-Chan Oh
1,
Seok-Min Kim
1,
Lingzu Kong
1,4,
Jesang Ko
2 and
Tae-Don Kim
1,3,*
1
Center for Cell and Gene Therapy, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea
2
Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea
3
KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon 34113, Republic of Korea
4
Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 34134, Republic of Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(19), 10326; https://doi.org/10.3390/ijms251910326
Submission received: 11 September 2024 / Revised: 23 September 2024 / Accepted: 24 September 2024 / Published: 25 September 2024
(This article belongs to the Section Molecular Oncology)
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Abstract

Cancer therapies have evolved from traditional chemotherapy to more precise molecular-targeted immunotherapies, which have been associated with improved side effects and outcomes. These modern strategies rely on cancer-specific biomarkers that differentiate malignant from normal cells. The B7 family of immune checkpoint molecules is crucial for cancer immune evasion and a prime therapeutic target. B7-H6, a recently identified member of the B7 family, has emerged as a promising therapeutic target. Unlike other B7 proteins, B7-H6 is not expressed in healthy tissues but is upregulated in several cancers. It binds to NKp30, activating natural killer (NK) cells and triggering immune responses against cancer cells. This review explores the expression of B7-H6 in different cancers, the factors that regulate its expression, and its intrinsic and extrinsic pathways. Additionally, we discuss potential anticancer therapies targeting B7-H6, highlighting its significance in advancing precision medicine. Understanding the role of B7-H6 in cancer immunity may inform the development of appropriate therapies that exploit its cancer-specific expression.
Keywords: B7-H6; NKp30; cancer-specific target; targeted therapy B7-H6; NKp30; cancer-specific target; targeted therapy

Share and Cite

MDPI and ACS Style

Lee, S.; Kim, J.H.; Jang, I.-H.; Jo, S.; Lee, S.Y.; Oh, S.-C.; Kim, S.-M.; Kong, L.; Ko, J.; Kim, T.-D. Harnessing B7-H6 for Anticancer Immunotherapy: Expression, Pathways, and Therapeutic Strategies. Int. J. Mol. Sci. 2024, 25, 10326. https://doi.org/10.3390/ijms251910326

AMA Style

Lee S, Kim JH, Jang I-H, Jo S, Lee SY, Oh S-C, Kim S-M, Kong L, Ko J, Kim T-D. Harnessing B7-H6 for Anticancer Immunotherapy: Expression, Pathways, and Therapeutic Strategies. International Journal of Molecular Sciences. 2024; 25(19):10326. https://doi.org/10.3390/ijms251910326

Chicago/Turabian Style

Lee, Sunyoung, Ji Hyun Kim, In-Hwan Jang, Seona Jo, Soo Yun Lee, Se-Chan Oh, Seok-Min Kim, Lingzu Kong, Jesang Ko, and Tae-Don Kim. 2024. "Harnessing B7-H6 for Anticancer Immunotherapy: Expression, Pathways, and Therapeutic Strategies" International Journal of Molecular Sciences 25, no. 19: 10326. https://doi.org/10.3390/ijms251910326

APA Style

Lee, S., Kim, J. H., Jang, I.-H., Jo, S., Lee, S. Y., Oh, S.-C., Kim, S.-M., Kong, L., Ko, J., & Kim, T.-D. (2024). Harnessing B7-H6 for Anticancer Immunotherapy: Expression, Pathways, and Therapeutic Strategies. International Journal of Molecular Sciences, 25(19), 10326. https://doi.org/10.3390/ijms251910326

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