Abstract
Plant-derived medicinal materials have significant potential and promising applications in wound healing and skin regeneration. This study aims to develop a plant-based extract hydrogel from Bletilla striata (Thunb.Reichb.f.), specifically a glucosyloxybenzyl 2-isobutylmalates extract (B), and characterize its potential effects on wound healing. We synthesized the hydrogel using carbomer (C), glycerol (G), and triethanolamine (T) as the matrix, incorporating B into the hydrogel base, and evaluated its physical and chemical properties. In vitro tests assessed the biocompatibility of the glucosyloxybenzyl 2-isobutylmalates-carbomer-glycerol-triethanolamine (B-CGT) hydrogel and its effects on cell proliferation, migration, and adhesion. Animal model experiments evaluated its potential to promote wound healing. The results showed that the prepared B-CGT hydrogel possessed a good three-dimensional network structure and stability, demonstrating significant free radical scavenging capacity in antioxidant tests. In cell experiments, the B-CGT hydrogel exhibited no potential cytotoxicity and showed good hemocompatibility and promotion of cell proliferation. Animal experiments indicated that wounds treated with the B-CGT hydrogel healed significantly faster, with improved formation of new epithelial tissue and collagen. This study suggests that the developed B-CGT hydrogel is a promising candidate for wound dressings, with excellent physicochemical properties and controlled drug release capabilities, effectively promoting the wound healing process.
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MDPI and ACS Style
Ran, F.; Mu, K.; Liu, G.; Liu, Y.; Pang, Y.; Feng, G.; Zhou, L.; Peng, L.
Preparation, Characterization, and Wound Healing Promotion of Hydrogels Containing Glucosyloxybenzyl 2-Isobutylmalates Extract from Bletilla striata (Thunb.) Reichb.f. Int. J. Mol. Sci. 2024, 25, 10563.
https://doi.org/10.3390/ijms251910563
AMA Style
Ran F, Mu K, Liu G, Liu Y, Pang Y, Feng G, Zhou L, Peng L.
Preparation, Characterization, and Wound Healing Promotion of Hydrogels Containing Glucosyloxybenzyl 2-Isobutylmalates Extract from Bletilla striata (Thunb.) Reichb.f. International Journal of Molecular Sciences. 2024; 25(19):10563.
https://doi.org/10.3390/ijms251910563
Chicago/Turabian Style
Ran, Fei, Kailang Mu, Gang Liu, Yuchen Liu, Yuxin Pang, Guo Feng, Lingli Zhou, and Leqiang Peng.
2024. "Preparation, Characterization, and Wound Healing Promotion of Hydrogels Containing Glucosyloxybenzyl 2-Isobutylmalates Extract from Bletilla striata (Thunb.) Reichb.f" International Journal of Molecular Sciences 25, no. 19: 10563.
https://doi.org/10.3390/ijms251910563
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