The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms

Diniz, Daniel Guerreiro; Bento-Torres, João; da Costa, Victor Oliveira; Carvalho, Josilayne Patricia Ramos; Tomás, Alessandra Mendonça; Galdino de Oliveira, Thaís Cristina; Soares, Fernanda Cabral; de Macedo, Liliane Dias e Dias; Jardim, Naina Yuki Vieira; Bento-Torres, Natáli Valim Oliver; Anthony, Daniel Clive; Brites, Dora; Picanço Diniz, Cristovam Wanderley

doi:10.3390/ijms251910757

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The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms

by

Daniel Guerreiro Diniz

^1,2,3

,

João Bento-Torres

^3,4

,

Victor Oliveira da Costa

³

,

Josilayne Patricia Ramos Carvalho

^3,4

,

Alessandra Mendonça Tomás

^3,5

,

Thaís Cristina Galdino de Oliveira

^3,6,

Fernanda Cabral Soares

³,

Liliane Dias e Dias de Macedo

^3,7,

Naina Yuki Vieira Jardim

^3,7,8,

Natáli Valim Oliver Bento-Torres

^3,4,*

,

Daniel Clive Anthony

⁹

,

Dora Brites

^10,11

and

Cristovam Wanderley Picanço Diniz

^2,3,8

¹

Laboratório de Microscopia Eletrônica, Instituto Evandro Chagas, Seção de Hepatologia, Belém 66.093-020, Pará, Brazil

²

Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém 66.073-005, Pará, Brazil

³

Laboratório de Investigações em Neurodegeneração e Infecção, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém 66.073-005, Pará, Brazil

⁴

Programa de Pós-Graduação em Ciências do Movimento Humano, Universidade Federal do Pará, Belém 66.050-160, Pará, Brazil

⁵

Campus Samabaia, Universidade Federal de Goiás (EBTT), CEPAE, Goiânia 74.001-970, Goiás, Brazil

⁶

Faculdade de Ceilândia, Ceilândia, Universidade de Brasília, Brasília 72.220-900, Brazil

⁷

Campus Tucurui, Universidade do Estado do Pará, Tucurui 68.455-210, Pará, Brazil

⁸

Programa de Pós-Graduação em Neurociências e Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66.075-110, Pará, Brazil

⁹

Laboratory of Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford OX1 2JD, UK

¹⁰

Faculty of Pharmacy, Department of Pharmaceutical Sciences and Medicines, Universidade de Lisboa, 1649-003 Lisbon, Portugal

¹¹

Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa), Universidade de Lisboa, 1649-003 Lisbon, Portugal

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Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2024, 25(19), 10757; https://doi.org/10.3390/ijms251910757 (registering DOI)

Submission received: 16 August 2024 / Revised: 23 September 2024 / Accepted: 27 September 2024 / Published: 6 October 2024

(This article belongs to the Section Molecular Neurobiology)

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Abstract

With the aging of the global population, neurodegenerative diseases are emerging as a major public health issue. The adoption of a less sedentary lifestyle has been shown to have a beneficial effect on cognitive decline, but the molecular mechanisms responsible are less clear. Here we provide a detailed analysis of the complex molecular, cellular, and systemic mechanisms underlying age-related cognitive decline and how lifestyle choices influence these processes. A review of the evidence from animal models, human studies, and postmortem analyses emphasizes the importance of integrating physical exercise with cognitive, multisensory, and motor stimulation as part of a multifaceted approach to mitigating cognitive decline. We highlight the potential of these non-pharmacological interventions to address key aging hallmarks, such as genomic instability, telomere attrition, and neuroinflammation, and underscore the need for comprehensive and personalized strategies to promote cognitive resilience and healthy aging.

Keywords: age-related cognitive decline; immunosenescence; neurodegeneration; neuroinflammation; oxidative stress; physical exercise; non-pharmacological interventions; therapeutic interventions; synaptic dysfunction

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MDPI and ACS Style

Diniz, D.G.; Bento-Torres, J.; da Costa, V.O.; Carvalho, J.P.R.; Tomás, A.M.; Galdino de Oliveira, T.C.; Soares, F.C.; de Macedo, L.D.e.D.; Jardim, N.Y.V.; Bento-Torres, N.V.O.; et al. The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms. Int. J. Mol. Sci. 2024, 25, 10757. https://doi.org/10.3390/ijms251910757

AMA Style

Diniz DG, Bento-Torres J, da Costa VO, Carvalho JPR, Tomás AM, Galdino de Oliveira TC, Soares FC, de Macedo LDeD, Jardim NYV, Bento-Torres NVO, et al. The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms. International Journal of Molecular Sciences. 2024; 25(19):10757. https://doi.org/10.3390/ijms251910757

Chicago/Turabian Style

Diniz, Daniel Guerreiro, João Bento-Torres, Victor Oliveira da Costa, Josilayne Patricia Ramos Carvalho, Alessandra Mendonça Tomás, Thaís Cristina Galdino de Oliveira, Fernanda Cabral Soares, Liliane Dias e Dias de Macedo, Naina Yuki Vieira Jardim, Natáli Valim Oliver Bento-Torres, and et al. 2024. "The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms" International Journal of Molecular Sciences 25, no. 19: 10757. https://doi.org/10.3390/ijms251910757

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The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms

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