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Volume 25
Issue 2
10.3390/ijms25021347
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Article
Peer-Review Record

SumVg: Total Heritability Explained by All Variants in Genome-Wide Association Studies Based on Summary Statistics with Standard Error Estimates

Int. J. Mol. Sci. 2024, 25(2), 1347; https://doi.org/10.3390/ijms25021347
by Hon-Cheong So 1,2,3,4,5,6,7,*, Xiao Xue 1, Zhijie Ma 1 and Pak-Chung Sham 8
Reviewer 1: Anonymous
Reviewer 2:
Lan Xiong
Reviewer 3:
Suvo Chatterjee
Int. J. Mol. Sci. 2024, 25(2), 1347; https://doi.org/10.3390/ijms25021347
Submission received: 13 October 2023 / Revised: 15 January 2024 / Accepted: 16 January 2024 / Published: 22 January 2024
(This article belongs to the Collection Feature Papers in “Molecular Biology”)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

My comments are included in the attached file.

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

This is an interesting study that report a self-developed program to estimate the SE of SNP-based heritability from GWAS summary statistics by comparing several resampling-based approaches. They have also validated their method by applying the program to estimate SNP-based 22 heritability of 12 immune-related traits (levels of cytokines and growth factors). The results seems consistent and convincing, which could be useful for researchers in the field. I only suggest that the main results from Table 2&4 could be better represented and illustrated in more visually effective figures?   

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

My comments are in the attached word file.

Comments for author File: Comments.pdf

Comments on the Quality of English Language

The paper has minor typographical errors which needs to be corrected.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

Comments and Suggestions for Authors

I thank the authors for addressing my concerns. I only have one comment. In the revision letter the authors have agreed to several points that I highlighted as limitations to their current approach. However, I did not see them mentioned in the discussion section of the revised manuscript. Can the authors clearly mention all the current limitations (in a paragraph or two) in their discussion section so that the readers/users become aware of them.

Other than the above corrections, I have no further comment.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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