The Laboratory Diagnosis of Malaria: A Focus on the Diagnostic Assays in Non-Endemic Areas

Round 1

Reviewer 1 Report

This research is comprehensive review article about options for the laboratory diagnosis of malaria. As a disease which affects millions of people worldwide, with the highest morbidity and mortality rates in Africa and Southeast Asia, malaria is always the attractive topic. In that sense, there is importance in publishing this review article, but I will give some suggestions which will make it better.  

Unrelated to the fact that the primary topic of this article is the laboratory diagnosis of malaria, I think it would be necessary to add a section in the introduction about: drug and vector resistance, current therapeutic options and current vaccine.

Also, it would be necessary to point out that due to climate change and mass migration of people, indigenous cases of malaria are increasingly appearing sporadically (Corsica, Italy, Spain) or even as local epidemics (Greece), in countries or regions where the disease was considered eradicated.

Author Response

We thank the reviewer for the positive evaluation of our work and the suggestions to add some considerations in the Introduction.

According the reviewer's suggestions we have included in the Introduction a short section about drug and vector resistance, current therapeutic options and current vaccine. 

Moreover, in the Discussion it was pointed out that due to climate change and mass migration of people, indigenous cases of malaria are increasingly appearing sporadically (Corsica, Italy, Spain) or even as local epidemics (Greece), in countries or regions where the disease was considered eradicated.

Reviewer 2 Report

Please see the attached pdf with areas needing attention highlighted and comments on some suggestions. My only issue with the paper is the English used and I suggest extensive editing for readability and clarity.

Comments for author File: Comments.pdf

see above

Author Response

We thank the reviewer for the positive evaluation of our work.

We are sorry for the typing errors in some words and the three sentences highlighted in the reviewer's form considered too long. We have revised the text and modified it accordingly to the reviewer's suggestions.