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Volume 25
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Article

Morphological Evidence for a Unique Neuromuscular Functional Unit of the Human Vocalis Muscle

by
Rareș-Vasile Tracicaru
1,2,*,
Lars Bräuer
2,
Michael Döllinger
3,
Martin Schicht
2,
Bernhard Tillmann
4,
Delia Hînganu
1,
Liliana Hristian
5,
Marius Valeriu Hînganu
1,† and
Friedrich Paulsen
2,†
1
Department of Morphofunctional Sciences, Anatomy and Embryology, Grigore T Popa University of Medicine and Pharmacy Iași, University Street No 16, 700115 Iași, Romania
2
Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätstraße 19, 91054 Erlangen, Germany
3
Laboratory for Computational Medicine, Division of Phoniatrics and Pediatric Audiology, Department of Otorhinolaryngology Head & Neck Surgery, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Waldstr. 21, 91054 Erlangen, Germany
4
Anatomical Institute, Christian-Albrechts-Universität of Kiel, Otto-Hahn-Platz 8, 24118 Kiel, Germany
5
Department of Engineering and Design of Textile Products, “Gheorghe Asachi” Technical University of Iași, 700050 Iași, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2024, 25(22), 11916; https://doi.org/10.3390/ijms252211916
Submission received: 16 October 2024 / Revised: 29 October 2024 / Accepted: 4 November 2024 / Published: 6 November 2024
(This article belongs to the Section Molecular Biology)
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Abstract

Human vocalization is a complex process that is still only partially understood. Previous studies have suggested the possibility of a localized neuromuscular network of the larynx. Here we investigate this structure in human dissection specimens using multiple immunofluorescence and transmission electron microscopy (TEM). In the area of the pars interna of the thyroarytenoid muscle, muscle fibers are present that are clearly differentiated from skeletal or cardiac muscle cells and show an intermediate ultrastructure. In addition, intramuscular neurons are present that are detectable by both electron and fluorescence microscopy and may have a sensory function in a local neuronal network. Also, several types of sensory and motor synapses are detectable and distributed throughout the pars interna of the thyroarytenoid muscle, with multisynaptic muscle fibers being a common feature. These findings suggest the existence of a previously unrecognized type of muscle fiber coupled to an intramuscular neuronal network, the presence of which could explain functional peculiarities at the laryngeal level.
Keywords: larynx; laryngeal muscles; laryngeal nerves; electron microscopy; immunofluorescence; neural network; synapses; neuromuscular junctions; voice formation; neurolaryngology larynx; laryngeal muscles; laryngeal nerves; electron microscopy; immunofluorescence; neural network; synapses; neuromuscular junctions; voice formation; neurolaryngology

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MDPI and ACS Style

Tracicaru, R.-V.; Bräuer, L.; Döllinger, M.; Schicht, M.; Tillmann, B.; Hînganu, D.; Hristian, L.; Hînganu, M.V.; Paulsen, F. Morphological Evidence for a Unique Neuromuscular Functional Unit of the Human Vocalis Muscle. Int. J. Mol. Sci. 2024, 25, 11916. https://doi.org/10.3390/ijms252211916

AMA Style

Tracicaru R-V, Bräuer L, Döllinger M, Schicht M, Tillmann B, Hînganu D, Hristian L, Hînganu MV, Paulsen F. Morphological Evidence for a Unique Neuromuscular Functional Unit of the Human Vocalis Muscle. International Journal of Molecular Sciences. 2024; 25(22):11916. https://doi.org/10.3390/ijms252211916

Chicago/Turabian Style

Tracicaru, Rareș-Vasile, Lars Bräuer, Michael Döllinger, Martin Schicht, Bernhard Tillmann, Delia Hînganu, Liliana Hristian, Marius Valeriu Hînganu, and Friedrich Paulsen. 2024. "Morphological Evidence for a Unique Neuromuscular Functional Unit of the Human Vocalis Muscle" International Journal of Molecular Sciences 25, no. 22: 11916. https://doi.org/10.3390/ijms252211916

APA Style

Tracicaru, R.-V., Bräuer, L., Döllinger, M., Schicht, M., Tillmann, B., Hînganu, D., Hristian, L., Hînganu, M. V., & Paulsen, F. (2024). Morphological Evidence for a Unique Neuromuscular Functional Unit of the Human Vocalis Muscle. International Journal of Molecular Sciences, 25(22), 11916. https://doi.org/10.3390/ijms252211916

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