Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases

Xing, Cencan; Chen, Hongyu; Bi, Wangyu; Lei, Tong; Hang, Zhongci; Du, Hongwu

doi:10.3390/ijms252413446

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Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases

by

Cencan Xing

^1,2,†,

Hongyu Chen

^1,2,†,

Wangyu Bi

^1,2,

Tong Lei

²,

Zhongci Hang

^1,2 and

Hongwu Du

^1,2,*

¹

Daxing Research Institute, University of Science and Technology Beijing, Beijing 100083, China

²

School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2024, 25(24), 13446; https://doi.org/10.3390/ijms252413446

Submission received: 5 November 2024 / Revised: 7 December 2024 / Accepted: 13 December 2024 / Published: 15 December 2024

(This article belongs to the Special Issue Potential Prevention and Treatment of Neurodegenerative Disorders)

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Abstract

There is increasing interest in the potential therapeutic role of 5-HT (serotonin) in the treatment of neurodegenerative diseases, which are characterized by the progressive degeneration and death of nerve cells. 5-HT is a vital neurotransmitter that plays a central role in regulating mood, cognition, and various physiological processes in the body. Disruptions in the 5-HT system have been linked to several neurological and psychiatric disorders, making it an attractive target for therapeutic intervention. Although the exact causes of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) are not fully understood, researchers believe that regulating the 5-HT system could help alleviate symptoms and potentially slow the progression of these diseases. Here, we delve into the potential of harnessing 5-HT as a therapeutic target for the treatment of neurodegenerative diseases. It is important to note that the current clinical drugs targeting 5-HT are still limited in the treatment of these complex diseases. Therefore, further research and clinical trials are needed to evaluate the feasibility and effectiveness of its clinical application.

Keywords: 5-HT; clinical trials; neurodegenerative diseases; therapeutic target

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MDPI and ACS Style

Xing, C.; Chen, H.; Bi, W.; Lei, T.; Hang, Z.; Du, H. Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases. Int. J. Mol. Sci. 2024, 25, 13446. https://doi.org/10.3390/ijms252413446

AMA Style

Xing C, Chen H, Bi W, Lei T, Hang Z, Du H. Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases. International Journal of Molecular Sciences. 2024; 25(24):13446. https://doi.org/10.3390/ijms252413446

Chicago/Turabian Style

Xing, Cencan, Hongyu Chen, Wangyu Bi, Tong Lei, Zhongci Hang, and Hongwu Du. 2024. "Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases" International Journal of Molecular Sciences 25, no. 24: 13446. https://doi.org/10.3390/ijms252413446

APA Style

Xing, C., Chen, H., Bi, W., Lei, T., Hang, Z., & Du, H. (2024). Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases. International Journal of Molecular Sciences, 25(24), 13446. https://doi.org/10.3390/ijms252413446

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Targeting 5-HT Is a Potential Therapeutic Strategy for Neurodegenerative Diseases

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