Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches

Ramirez-Falcon, Melody; Suarez-Pajes, Eva; Flores, Carlos

doi:10.3390/ijms252413611

Open AccessReview

Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches

by

Melody Ramirez-Falcon

^1,2,

Eva Suarez-Pajes

¹ and

Carlos Flores

^1,2,3,4,*

¹

Research Unit, Hospital Universitario Ntra. Sra. de Candelaria, Instituto de Investigación Sanitaria de Canarias, 38010 Santa Cruz de Tenerife, Spain

²

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain

³

Genomics Division, Instituto Tecnológico y de Energías Renovables, Granadilla de Abona, 38600 Santa Cruz de Tenerife, Spain

⁴

Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, 35450 Las Palmas de Gran Canaria, Spain

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2024, 25(24), 13611; https://doi.org/10.3390/ijms252413611

Submission received: 16 November 2024 / Revised: 16 December 2024 / Accepted: 17 December 2024 / Published: 19 December 2024

(This article belongs to the Collection Feature Papers in Molecular Pathology, Diagnostics, and Therapeutics)

Download

Browse Figure

Versions Notes

Abstract

Since their discovery, corticosteroids have been widely used in the treatment of several diseases, including asthma, acute lymphoblastic leukemia, chronic obstructive pulmonary disease, and many other conditions. However, it has been noted that some patients develop undesired side effects or even fail to respond to treatment. The reasons behind this have not yet been fully elucidated. This poses a significant challenge to effective treatment that needs to be addressed urgently. Recent genomic, transcriptomic, and other omics-based approximations have begun to shed light into the genetic factors influencing interindividual variability in corticosteroid efficacy and its side effects. Here, we comprehensively revise the recent literature on corticosteroid response in various critical and chronic diseases, with a focus on omics approaches, and highlight existing knowledge gaps where further investigation is urgently needed.

Keywords: corticosteroids; glucocorticoids; genomics; transcriptomics; epigenomics; proteomics; metabolomics

Share and Cite

MDPI and ACS Style

Ramirez-Falcon, M.; Suarez-Pajes, E.; Flores, C. Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches. Int. J. Mol. Sci. 2024, 25, 13611. https://doi.org/10.3390/ijms252413611

AMA Style

Ramirez-Falcon M, Suarez-Pajes E, Flores C. Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches. International Journal of Molecular Sciences. 2024; 25(24):13611. https://doi.org/10.3390/ijms252413611

Chicago/Turabian Style

Ramirez-Falcon, Melody, Eva Suarez-Pajes, and Carlos Flores. 2024. "Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches" International Journal of Molecular Sciences 25, no. 24: 13611. https://doi.org/10.3390/ijms252413611

APA Style

Ramirez-Falcon, M., Suarez-Pajes, E., & Flores, C. (2024). Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches. International Journal of Molecular Sciences, 25(24), 13611. https://doi.org/10.3390/ijms252413611

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI