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Volume 25
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Review

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

by
Beatriz G. Bernardes
1,2,
Anabela Veiga
1,3,4,
Joana Barros
5,6,
Carlos A. García-González
2,* and
Ana Leite Oliveira
1,*
1
Universidade Católica Portuguesa, CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal
2
AerogelsLab, I+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, iMATUS and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain
3
LEPABE-Laboratory for Process Engineering, Environment, Biotechnology & Energy, Department of Chemical Engineering, Faculty of Engineering, University of Porto, R. Dr. Roberto Frias, 4200-465 Porto, Portugal
4
ALiCE-Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
5
i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal
6
INEB-Instituto de Engenharia Biomédica, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(6), 3133; https://doi.org/10.3390/ijms25063133
Submission received: 12 January 2024 / Revised: 27 February 2024 / Accepted: 4 March 2024 / Published: 8 March 2024
(This article belongs to the Special Issue Sustainable Approaches in Skin Conditions 2.0)
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Abstract

The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.
Keywords: silk proteins; drug carriers; particulate systems; wound healing; tissue engineering silk proteins; drug carriers; particulate systems; wound healing; tissue engineering

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MDPI and ACS Style

Bernardes, B.G.; Veiga, A.; Barros, J.; García-González, C.A.; Oliveira, A.L. Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration. Int. J. Mol. Sci. 2024, 25, 3133. https://doi.org/10.3390/ijms25063133

AMA Style

Bernardes BG, Veiga A, Barros J, García-González CA, Oliveira AL. Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration. International Journal of Molecular Sciences. 2024; 25(6):3133. https://doi.org/10.3390/ijms25063133

Chicago/Turabian Style

Bernardes, Beatriz G., Anabela Veiga, Joana Barros, Carlos A. García-González, and Ana Leite Oliveira. 2024. "Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration" International Journal of Molecular Sciences 25, no. 6: 3133. https://doi.org/10.3390/ijms25063133

APA Style

Bernardes, B. G., Veiga, A., Barros, J., García-González, C. A., & Oliveira, A. L. (2024). Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration. International Journal of Molecular Sciences, 25(6), 3133. https://doi.org/10.3390/ijms25063133

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