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Review

Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature

by
Nicole Natarelli
1,
Nimrit Gahoonia
2,
Shaliz Aflatooni
1,
Sahibjot Bhatia
3 and
Raja K. Sivamani
3,4,5,6,*
1
Morsani College of Medicine, University of South Florida, 560 Channelside Drive, Tampa, FL 33602, USA
2
College of Osteopathic Medicine, Touro University, 1310 Club Dr, Vallejo, CA 94592, USA
3
College of Medicine, California Northstate University, 9700 W Taron Dr, Elk Grove, CA 95757, USA
4
Integrative Skin Science and Research, 1495 River Park Drive, Sacramento, CA 95819, USA
5
Pacific Skin Institute, 1495 River Park Dr Suite 200, Sacramento, CA 95815, USA
6
Department of Dermatology, University of California-Davis, 3301 C St #1400, Sacramento, CA 95816, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(6), 3303; https://doi.org/10.3390/ijms25063303
Submission received: 19 January 2024 / Revised: 4 March 2024 / Accepted: 11 March 2024 / Published: 14 March 2024
(This article belongs to the Section Molecular Biology)
Versions Notes

Abstract

Mitochondria are eukaryotic cellular organelles that function in energy metabolism, ROS production, and programmed cell death. Cutaneous epithelial and hair follicle dermal papilla cells are energy-rich cells that thereby may be affected by mitochondrial dysfunction and DNA mutation accumulation. In this review, we aimed to summarize the medical literature assessing dermatologic conditions and outcomes associated with mitochondrial dysfunction. A search of PubMed and Embase was performed with subsequent handsearching to retrieve additional relevant articles. Mitochondrial DNA (mtDNA) deletions, mutation accumulation, and damage are associated with phenotypic signs of cutaneous aging, hair loss, and impaired wound healing. In addition, several dermatologic conditions are associated with aberrant mitochondrial activity, such as systemic lupus erythematosus, psoriasis, vitiligo, and atopic dermatitis. Mouse model studies have better established causality between mitochondrial damage and dermatologic outcomes, with some depicting reversibility upon restoration of mitochondrial function. Mitochondrial function mediates a variety of dermatologic conditions, and mitochondrial components may be a promising target for therapeutic strategies.
Keywords: mitochondria; dermatology; UVR; aging; hair loss; wound healing; lupus; psoriasis; vitiligo; atopic dermatitis mitochondria; dermatology; UVR; aging; hair loss; wound healing; lupus; psoriasis; vitiligo; atopic dermatitis

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MDPI and ACS Style

Natarelli, N.; Gahoonia, N.; Aflatooni, S.; Bhatia, S.; Sivamani, R.K. Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature. Int. J. Mol. Sci. 2024, 25, 3303. https://doi.org/10.3390/ijms25063303

AMA Style

Natarelli N, Gahoonia N, Aflatooni S, Bhatia S, Sivamani RK. Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature. International Journal of Molecular Sciences. 2024; 25(6):3303. https://doi.org/10.3390/ijms25063303

Chicago/Turabian Style

Natarelli, Nicole, Nimrit Gahoonia, Shaliz Aflatooni, Sahibjot Bhatia, and Raja K. Sivamani. 2024. "Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature" International Journal of Molecular Sciences 25, no. 6: 3303. https://doi.org/10.3390/ijms25063303

APA Style

Natarelli, N., Gahoonia, N., Aflatooni, S., Bhatia, S., & Sivamani, R. K. (2024). Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature. International Journal of Molecular Sciences, 25(6), 3303. https://doi.org/10.3390/ijms25063303

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