Synthesis of Antiprotozoal 2-(4-Alkyloxyphenyl)-Imidazolines and Imidazoles and Their Evaluation on Leishmania mexicana and Trypanosoma cruzi
, Jorge Hernández-Calderón 1, Luvia E. Sánchez-Torres 3,*, BenjamÃn Nogueda-Torres 4 and Alicia Reyes-Arellano 1,*Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsSee attached pdf file
Comments for author File: 
Comments.pdf
Author Response
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Author Response File: Author Response.pdf
Reviewer 2 Report
Comments and Suggestions for AuthorsIn this manuscript Reyes-Arellano and coworkers present a study in which they synthesize 2-(4-alkyloxyphenyl)-imidazolines and imidazoles, evaluating their potential as antiprotozoal agents against Leishmania mexicana and Trypanosoma cruzi, addressing the critical need for novel treatments in neglected tropical diseases like Chagas disease and leishmaniasis. Despite the familiarity of the synthetic reactions and molecules, the study's significance lies in its promising in vitro bioactivity results. The compounds exhibited intriguing bioactivity against the targeted protozoa, suggesting their potential as new therapeutic candidates. Given the scarcity of effective treatments for these diseases, particularly in Chagas disease where the drug discovery pipeline is thin, the findings hold importance for both the scientific community and society at large. While in vivo bioassays would enhance the manuscript's impact, the compelling in vitro results justify consideration for publication in the International Journal of Molecular Science. This research contributes to advancing the understanding of potential treatments for neglected tropical diseases, offering hope for improved healthcare outcomes in regions affected by these conditions.
Author Response
Thank you very much for the Review of the manuscript. We appreciate the time that you invested in this work. We would also like to thank you for
your comments on our work. We consider the manuscript was greatly improved
A POINT-BY-POINT REPLY
Does the introduction provide sufficient background and include all relevant references?
Response: References have been reviewed and we have standardized the format of all references.
Are all the cited references relevant to the research?
Response: We consider all the references are relevant to the research
Are the conclusions supported by the results?
Response: We consider the conclusions are supported by the results
