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Volume 26
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Review

NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis

by
Viorela-Elena Suciu
1,
Daniel-Corneliu Leucuța
2,*,†,
Andrei Mihai Măluțan
1,†,
Cristian Iuhas
1,
Mihaela Oancea
1,
Carmen Elena Bucuri
1,3,
Maria Patricia Roman
1,
Cristina Ormindean
1,
Dan Mihu
1 and
Răzvan Ciortea
1
1
2nd Department of Obstetrics and Gynecology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania
2
Department of Medical Informatics and Biostatistics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania
3
Emergency Military Clinical Hospital “Dr Constantin Papilian”, 400610 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2025, 26(13), 6272; https://doi.org/10.3390/ijms26136272 (registering DOI)
Submission received: 30 April 2025 / Revised: 17 June 2025 / Accepted: 26 June 2025 / Published: 28 June 2025
(This article belongs to the Section Molecular Oncology)
Versions Notes

Abstract

The aim of this study was to evaluate and synthesize the existing evidence on N-terminal pro-brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) as biomarkers for preeclampsia as compared with a healthy pregnant group, but also comparing them in early-onset preeclampsia (EOP) versus late-onset preeclampsia (LOP). Five electronic databases, PubMed, EMBASE, Web of Science, Scopus, and LILACS, were searched for studies on pregnant women comparing NT-proBNP and BNP levels in preeclampsia vs. healthy pregnancies and EOP vs. LOP. From the 752 identified records, 31 studies were included in the review, referring to 3915 participants. When comparing PE to healthy pregnancies and EOP to LOP, there was a considerable increase in NT-proBNP levels in the PE group, respectively, in EOP: 206.19 pg/mL (95% CI 139.68–272.69) (p ≤ 0.001) in the PE group, and 182.42 pg/mL (95% CI 99.65–265.19) (p ≤ 0.001) in the EOP group. Regarding BNP, the levels were higher in the PE group (30.13 (95% CI 17.22–43.04), p ≤ 0.001), respectively in the EOP group (33.35 pg/mL (95% CI 20.26–46.43), p ≤ 0.001). NT-proBNP and BNP levels are consistently elevated in preeclampsia compared to healthy pregnancies and in EOP compared to LOP.
Keywords: preeclampsia; biomarkers; brain natriuretic peptide preeclampsia; biomarkers; brain natriuretic peptide

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MDPI and ACS Style

Suciu, V.-E.; Leucuța, D.-C.; Măluțan, A.M.; Iuhas, C.; Oancea, M.; Bucuri, C.E.; Roman, M.P.; Ormindean, C.; Mihu, D.; Ciortea, R. NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2025, 26, 6272. https://doi.org/10.3390/ijms26136272

AMA Style

Suciu V-E, Leucuța D-C, Măluțan AM, Iuhas C, Oancea M, Bucuri CE, Roman MP, Ormindean C, Mihu D, Ciortea R. NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2025; 26(13):6272. https://doi.org/10.3390/ijms26136272

Chicago/Turabian Style

Suciu, Viorela-Elena, Daniel-Corneliu Leucuța, Andrei Mihai Măluțan, Cristian Iuhas, Mihaela Oancea, Carmen Elena Bucuri, Maria Patricia Roman, Cristina Ormindean, Dan Mihu, and Răzvan Ciortea. 2025. "NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 26, no. 13: 6272. https://doi.org/10.3390/ijms26136272

APA Style

Suciu, V.-E., Leucuța, D.-C., Măluțan, A. M., Iuhas, C., Oancea, M., Bucuri, C. E., Roman, M. P., Ormindean, C., Mihu, D., & Ciortea, R. (2025). NT-proBNP and BNP as Biomarkers for Preeclampsia: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 26(13), 6272. https://doi.org/10.3390/ijms26136272

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