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Peer-Review Record

HSPA1A Can Alleviate CFA-Induced Inflammatory Pain by Modulating Macrophages

Int. J. Mol. Sci. 2025, 26(19), 9591; https://doi.org/10.3390/ijms26199591
by Wenjie Zhang, Xiaojun Xie, Xiaomin Xiong and Feiyu Chen *
Reviewer 1: Anonymous
Reviewer 2:
Int. J. Mol. Sci. 2025, 26(19), 9591; https://doi.org/10.3390/ijms26199591
Submission received: 27 August 2025 / Revised: 26 September 2025 / Accepted: 30 September 2025 / Published: 1 October 2025
(This article belongs to the Section Molecular Immunology)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

My Comments are in attached word file.

Comments for author File: Comments.pdf

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Please the comments below:

  1. Define HSPA1A
  2. Author shows previous study being conducted in rats where overexpressing HSPA1A exhibit decreased expression of inflammation-associated proteins, with reduced inflammatory cytokines. Have there been any previous similar studies using mouse models? If not, is this the first study in mouse administering HSPA1A to investigate its effects? Why wasn’t rat considered for this study if that is well established in the literature.
  3. Il1b, make it consistent throughout the manuscript.
  4. Line 295- “This aligns with literature reports that HSPA1A reduces inflammation levels.” Need appropriate citation to validate this.
  5. A schematic summary figure would be very useful to illustrate findings.
  6. Figure legend and significance value, please define asterisk value based on statistics and not include everything. Example Fig 1 ** is not presented on the figure but is included in the legend. This can confuse the reader.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

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