Next Article in Journal
1,3-Bis(pyren-1-yl)imidazolium chloride (IPyr·HCl)
Previous Article in Journal
(2E)-3-(4-Dimethylaminophenyl)-1-(2,5-dimethylfuran-3-yl)-prop-2-en-1-one
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molbank
Volume 2011
Issue 2
10.3390/M728
molbank-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Short Note

8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one

by
Andrey A. Berezin
and
Panayiotis A. Koutentis
*
Department of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus
*
Author to whom correspondence should be addressed.
Molbank 2011, 2011(2), M728; https://doi.org/10.3390/M728
Submission received: 10 May 2011 / Accepted: 24 May 2011 / Published: 30 May 2011
Browse Figure
Versions Notes

Abstract

8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 1 (NS2028) reacts with [2-chloro-5-(trifluoromethyl)phenyl]boronic acid 2 (2 equiv), Pd(OAc)2 (10 mol%) and KOAc (4 equiv) in acetonitrile heated to ca. 110 °C (sealed tube) for 12 hours to give 8-[2-chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one 4 in 64% yield.
Keywords: soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling soluble guanylyl cyclase inhibitors; NS2028; benzoxazine; oxadiazole; Suzuki-Miyaura coupling
Graphical Abstract

Share and Cite

MDPI and ACS Style

Berezin, A.A.; Koutentis, P.A. 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank 2011, 2011, M728. https://doi.org/10.3390/M728

AMA Style

Berezin AA, Koutentis PA. 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank. 2011; 2011(2):M728. https://doi.org/10.3390/M728

Chicago/Turabian Style

Berezin, Andrey A., and Panayiotis A. Koutentis. 2011. "8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one" Molbank 2011, no. 2: M728. https://doi.org/10.3390/M728

APA Style

Berezin, A. A., & Koutentis, P. A. (2011). 8-[2-Chloro-5-(trifluoromethyl)phenyl]-4H-[1,2,4]oxadiazolo-[3,4-c][1,4]benzoxazin-1-one. Molbank, 2011(2), M728. https://doi.org/10.3390/M728

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop