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Short Note

Benzo[b]thiophene-2-carbaldehyde

by
Raffaella Mancuso
* and
Bartolo Gabriele
*
Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, Ponte Pietro Bucci 12/C, 87036 Arcavacata di Rende (CS), Italy
*
Authors to whom correspondence should be addressed.
Molbank 2014, 2014(2), M823; https://doi.org/10.3390/M823
Submission received: 3 March 2014 / Accepted: 8 May 2014 / Published: 12 May 2014

Abstract

:
A novel expedient synthesis of benzo[b]thiophene-2-carbaldehyde 2 is reported. It is based on the one-pot sequential reaction of methylthiobenzene 1 with BuLi and DMF to give 2 in 80% isolated yield.

Graphical Abstract

Benzo[b]thiophene-2-carbaldehyde 2 is a very important heterocycle derivative. It has been used as intermediate in organic synthesis for the preparation of a variety molecules [1,2,3,4], including biologically active compounds [5,6,7,8,9,10]. It is commonly prepared by formylation of benzo[b]thiophene with DMF [11] or other formylating agents [12,13] or by oxidation of benzo[b]thiophen-2-ylmethanol [14]. To the best of our knowledge, the only example of synthesis of 2 starting from an acyclic precursor is based on a 3-step procedure involving the reduction of 2-mercaptobenzoic acid followed by alkylation with bromoacetaldehyde dimethyl acetal and acid-promoted cyclization [15].
Here we report a simple and convenient method for the direct synthesis of 2 starting from unexpensive and commercially available methylthiobenzene 1. The reaction of 1 with an excess of BuLi and tetramethylethylenediamine (TMEDA) at 0–25 °C, followed by the one-pot reaction with DMF at room temperature and quenching with aqueous HCl, led to 2 with an 80% isolated yield (Scheme 1).
Formation of 1 can be rationalized according to the mechanism shown in Scheme 2. Thus, TMEDA-promoted double lithiation of 1 (at the ortho position and on the thiomethyl group, leading to dilithiated intermediate I), followed by diformylation of I with DMF, affords dialdehyde intermediate II, whose intramolecular aldol-type condensation eventually affords 2. Since Me2NLi is formed from the formylation process leading to II, the condensation of II may occur through α-deprotonation to give intermediate III, followed by intramolecular nucleophilic attack of the carbanion moiety to the aldehydic group, to give aldolate IV. Protonation of the latter by HCl followed by dehydration with simultaneous aromatization finally leads to 2 (Scheme 2).

Experimental

Benzo[b]thiophene-2-carbaldehyde 2: To a solution of methylthiobenzene 1 (1.0 g, 8.05 mmol) in hexane (30 mL) was added TMEDA (2.8 g, 24.1 mmol) under nitrogen and with stirring. The resulting stirred mixture was cooled at 0 °C for 10 min, and then a solution of BuLi in hexane (1.6 M; 15.1 mL, 24.2 mmol) was added dropwise at 0 °C under nitrogen. After additional stirring at 0 °C for 15 min and at RT for 24 h, the mixture was cooled with the aid of a cold water bath, and anhydrous DMF (2.1 mL, 27.4 mmol) was slowly added with vigorous stirring. The resulting mixture was allowed to stir under nitrogen at RT for 24 h. The reaction was quenched with aqueous HCl (1 M, 40 mL) and phases were separated. The organic phase was washed with 1 M HCl (2 × 20 mL), water (2 × 20 mL) and brine (20 mL) to give organic phase I. The collected acidic aqueous layers were extracted with Et2O (3 × 80 mL), and the collected ethereal phases were washed with water (2 × 80 mL) and brine (80 mL) to give organic phase II. The collected organic phases I + II were then dried over Na2SO4. After filtration and elimination of the solvent by rotary evaporation, the product was recovered by column chropatography on silica gel (Merck, Darmstadt, Germany, 70–230 mesh) using as eluent pure hexane to 8:2 hexane/AcOEt. Yield: 1.05 g (80% based on starting 1). Pale yellow solid, m.p. 27–28 °C. IR (film): ν = 2826 (w), 1672 (s), 1593 (w), 1518 (m), 1432 (w), 1256 (w), 1225 (m), 1137 (m), 868 (w), 841 (w), 749 (m), 726 (m) cm−1; 1H-NMR (300 MHz, CDCl3): δ = 10.08 (s, 1 H, CHO), 7.99 (s, 1 H, =CH), 7.95–7.84 (m, 2 H, aromatic), 7.54–7.38 (m, 2 H, aromatic); 13C-NMR (75 MHz, CDCl3): δ = 184.1, 143.9, 143.1, 138.9, 133.7, 128.1, 126.3, 125.4, 123.4; GC-MS: m/z = 162 (100) [M+], 161 (99), 134 (24), 133 (32), 108 (4), 89 (50), 63 (22); anal. calcd for C9H6OS (162.21): C, 66.64; H, 3.73; S, 19.77; found C, 66.71; H, 3.72; N, 19.74.

Supplementary materials

Supplementary File 1Supplementary File 2Supplementary File 3

Acknowledgments

Thanks are due to the European Commission, FSE (Fondo Sociale Europeo) and Calabria Region for a fellowship grant to R. M.

Author Contributions

The authors contributed equally to this work.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Sharif, M.; Opalach, J.; Langer, P.; Beller, M.; Wu, X.-F. Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes. RSC Adv. 2014, 4, 8–17. [Google Scholar] [CrossRef]
  2. Saadi, J.; Yamamoto, H. β-Siloxy-α-haloketones through highly diastereoselective single and double Mukaiyama aldol reactions. Chem. Eur. J. 2013, 19, 3842–3845. [Google Scholar] [CrossRef] [PubMed]
  3. Maity, S.; Naveen, T.; Sharma, U.; Maiti, D. Stereoselective nitration of olefins with tBuONO and TEMPO: Direct access to nitroolefins under metal-free conditions. Org. Lett. 2013, 15, 3384–3387. [Google Scholar] [CrossRef] [PubMed]
  4. Nguyen, T.T.B.; Lomberget, T.; Tran, N.C.; Barret, R. Synthesis of (Z) isomers of benzoheterocyclic derivatives of Combretastatin A-4: A comparative study of several methods. Tetrahedron 2013, 69, 2336–2347. [Google Scholar] [CrossRef]
  5. Trump, R.P.; Bresciani, S.; Cooper, A.W.J.; Tellam, J.P.; Wojno, J.; Blaikley, J.; Orband-Miller, L.A.; Kashatus, J.A.; Boudjelal, M.; Dawson, H.C.; et al. Optimized chemical probes for REV-ERBα. J. Med. Chem. 2013, 56, 4729–4737. [Google Scholar] [CrossRef] [PubMed]
  6. Penthala, N.R.; Sonar, V.N.; Horn, J.; Leggas, M.; Yadlapallia, J.S.K.B.; Crooks, P.A. Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents. Med. Chem. Commun. 2013, 4, 1073–1078. [Google Scholar] [CrossRef] [PubMed]
  7. Tiruveedhula, V.V.N.P.B.; Witzigmann, C.M.; Verma, R.; Kabir, M.S.; Rott, M.; Schwan, W.R.; Medina-Bielski, S.; Lane, M.; Close, W.; Polanowski, R.L.; et al. Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis. Bioorg. Med. Chem. 2013, 21, 7830–7840. [Google Scholar] [CrossRef] [PubMed]
  8. Zhong, Z.-J.; Zhang, D.-J.; Peng, Z.-G.; Li, Y.-H.; Shan, G.-Z.; Zuo, L.-M.; Wu, L.-T.; Li, S.-Y.; Gao, R.-M.; Li, Z.-R. Synthesis and antiviral activity of a novel class of (5-oxazolyl)phenylamines. Eur. J. Med. Chem. 2013, 69, 32–43. [Google Scholar] [CrossRef] [PubMed]
  9. Patel, R.V.; Patel, J.K.; Nile, S.H.; Park, S.W. Synthesis and biological evaluation of piperazinyl-2-(benzo)thiophen/-furan-2-yl-acetonitriles as Strecker reaction products. Lett. Drug Design Discov. 2013, 10, 462–470. [Google Scholar] [CrossRef]
  10. Nguyen, T.T.B.; Lomberget, T.; Tran, N.C.; Colomb, E.; Nachtergaele, L.; Thoret, S.; Dubois, J.; Guillaume, J.; Abdayem, R.; Haftek, M.; et al. Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4. Bioorg. Med. Chem. Lett. 2012, 22, 7227–7231. [Google Scholar] [CrossRef] [PubMed]
  11. Gigant, N.; Claveau, E.; Bouyssou, P.; Gillaizeau, I. Diversity-oriented synthesis of polycyclic diazinic scaffolds. Org. Lett. 2012, 14, 844–847. [Google Scholar] [CrossRef] [PubMed]
  12. Branytska, O.; Neumann, R. Synthesis of aromatic aldehydes by oxidative hydroxymethylation. Synlett 2004, 1575–1576. [Google Scholar] [CrossRef]
  13. Hopf, H.; Hucker, J.; Ernst, L. On the functionalization of [2.2](1,4)phenanthrenoparacyclophane. Eur. J. Org. Chem. 2007, 1891–1904. [Google Scholar] [CrossRef]
  14. Zhu, Y.; Zhao, B.; Shi, Y. Highly efficient Cu(I)-catalyzed oxidation of alcohols to ketones and aldehydes with diaziridinone. Org. Lett. 2013, 15, 992–995. [Google Scholar] [CrossRef] [PubMed]
  15. Hsiao, C.-N.; Bhagavatula, L.; Pariza, R.J. A practical synthesis of 2-carbonylbenzo[b]thiophenes. Synth. Commun. 1990, 20, 1687–1695. [Google Scholar] [CrossRef]
Scheme 1. Synthesis of benzo[b]thiophene-2-carbaldehyde 2 from methylthiobenzene 1.
Scheme 1. Synthesis of benzo[b]thiophene-2-carbaldehyde 2 from methylthiobenzene 1.
Molbank 2014 m823 sch001
Scheme 2. Plausible reaction mechanism for the formation of benzo[b]thiophene-2-carbaldehyde 2 from methylthiobenzene 1.
Scheme 2. Plausible reaction mechanism for the formation of benzo[b]thiophene-2-carbaldehyde 2 from methylthiobenzene 1.
Molbank 2014 m823 sch002

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MDPI and ACS Style

Mancuso, R.; Gabriele, B. Benzo[b]thiophene-2-carbaldehyde. Molbank 2014, 2014, M823. https://doi.org/10.3390/M823

AMA Style

Mancuso R, Gabriele B. Benzo[b]thiophene-2-carbaldehyde. Molbank. 2014; 2014(2):M823. https://doi.org/10.3390/M823

Chicago/Turabian Style

Mancuso, Raffaella, and Bartolo Gabriele. 2014. "Benzo[b]thiophene-2-carbaldehyde" Molbank 2014, no. 2: M823. https://doi.org/10.3390/M823

APA Style

Mancuso, R., & Gabriele, B. (2014). Benzo[b]thiophene-2-carbaldehyde. Molbank, 2014(2), M823. https://doi.org/10.3390/M823

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