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Communication

4-Acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one

by
Chiaki Akazaki
1,
Shun Kawabata
1 and
Hiroshi Nishino
2,*
1
Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, Kurokami 2-39-1, Kumamoto 860-8555, Japan
2
Department of Chemistry, Kumamoto University, Kurokami 2-39-1, Kumamoto 860-8555, Japan
*
Author to whom correspondence should be addressed.
Molbank 2016, 2016(4), M913; https://doi.org/10.3390/M913
Submission received: 7 September 2016 / Revised: 12 October 2016 / Accepted: 14 October 2016 / Published: 20 October 2016
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Abstract

:
The facile synthesis of 4-acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one (4) was achieved by the Mn(OAc)3-mediated aerobic oxidation of 2,4-pentanedione or the direct reaction of Mn(acac)3 in AcOH-TFE at room temperature under a dried air stream.

Graphical Abstract

1. Introduction

It is well-known that the oxidation of alkenes with tris(2,4-pentanedionato)manganese(III), Mn(acac)3, produces dihydrofurans 1 [1], which are also produced by the oxidation of a mixture of alkenes and 2,4-pentanedione (Hacac) with manganese(III) acetate dihydrate, Mn(OAc)3·2H2O. When the reactions are carried out at room temperature in air, 1,2-dioxan-3-ols 2 are produced [2] (Scheme 1). Both reactions would be affected by the formation of a by-product, 3-acetyl-4-hydroxyhex-3-ene-2,5-dione (3), which would be generated by a bimolecular coupling reaction of 2,4-pentanedione radicals [3]. However, the crystalline by-product is easy to remove from the dihydrofurans 1 and 1,2-dioxian-3-ols 2 by a chromatographic separation (Scheme 1).
The by-product 3 is attractive as a synthetic building block in many organic reactions because it is an electron-deficient alkene [4,5,6,7,8,9,10,11,12,13,14,15]. Therefore, we initially investigated the reaction of ketones [16], electron-rich heterocycles, and dienes [17]. However, all the reactions failed or gave an intractable mixture. The results were very confusing, and we doubted the structure of 3 since the cyclic keto-hemiacetal 4 should be rather more stable than the electron-deficient vinyl alcohol 3 (Scheme 2). In this paper, we discuss the characterization of the exact structure of the by-product 3, the optimization of the aerobic oxidation reaction, and the reaction mechanism.

2. Results

A single crystal of the by-product was successfully grown from CHCl3/hexane and subjected to an X-ray crystallographic measurement. As a result, we obtained the exact structure of the compound as 4-acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one (4) (Supplementary Materials). We were very surprised by the production of 4 and then scrutinized the reaction using Mn(III) complexes.
The reaction of Mn(acac)3 or Hacac with Mn(OAc)3 was carried out in acetic acid (AcOH) at room temperature in air or under an oxygen atmosphere from a mechanistic aspect [2], affording the furanone 4 in a yield similar to that reported in the literature (Scheme 3 and Table 1, Entries 2, 4, and 8) [1,2,3]. Removal of water led to a decreased yield (Entries 5 and 9). Although the yield did not change in the reaction using Mn(acac)3 under a dried air stream (Entry 3), it dramatically increased in the reaction of Hacac with Mn(OAc)3 (Entry 12). The addition of trifluoroethanol (TFE) [18,19,20] was fairly effective in the reaction of Mn(acac)3 (Entry 6), while it dramatically improved the yield of 4 in the reaction of Hacac with Mn(OAc)3 (compare Entry 8 with Entry 14). We recently found that formic acid displayed both an increasing reaction rate and product yield for the Mn(III)-based oxidative reaction [21]. The reaction was then carried out in the presence of formic acid. Unfortunately, despite acceleration of the reaction, it became complicated (Entry 10). It was also not effective to add sodium acetate (Entry 11) [22,23]. Eventually, we realized the maximum yield of 4 in the presence of trifluoroethanol under a dried air stream (Entry 15). Therefore, the optimized conditions in order to synthesize the furnone 4 in the direct method using Mn(acac)3 were in AcOH-TFE at room temperature in air for 12 h (Entry 6), while the best conditions in the reaction of Hacac with Mn(OAc)3 were in AcOH-TFE at room temperature under a dried air stream for 12 h (Entry 15).
In addition, the cyclic keto-hemiacetal 4 was easily transformed into the corresponding acetoxy-acetal 5 (89%) [2] and methoxy-acetal 6 (quant) (Scheme 4).

3. Discussion

The reaction was not effective under an argon atmosphere (Table 1, Entries 1, 7), but in air, the furanone 4 was produced as the sole product. Therefore, it was considered that the reaction must proceed according to the Mn(III)-mediated aerobic oxidation [2]. The one-electron oxidation of Mn(acac)3 or the manganese(III)-enolate complex formed in situ from the ligand-exchange reaction of Hacac with Mn(OAc)3 [2] gave the 1,3-dicarbonyl radicals A (Scheme 5), which underwent a head-to-head radical coupling reaction to produce the dimeric compound B. The 1,3-dicarbonyl radical A could be trapped by a radical scavenger such as xanthene and 2,6-di-tert-butyl-4-methylphenol (BHT) [24]. The dimeric compound B should be more reactive than Hacac, thus compound B would be further oxidized and followed by capture of the dissolved molecular oxygen to produce the peroxy radical C. Radical C should be reduced by Mn(II), affording the peroxy anions D and the reproduced Mn(III) species [25,26]. The peroxy anion D must be converted to 4-acetylhexane-2,3,5-trione (H) via the 1,2-dioxetane formation [27]. Alternatively, the Mn(III)-enolate complex F would be formed by the reaction of the anion D with Mn(III) species, followed by the Criegee-type oxidation [2,28] accompanying the addition of water to also produce the trione H since the reaction was suppressed under dry conditions (Entries 5, 9). Eventually, the trione H cyclized and the stable furanone 4 was isolated. The proposed mechanism is briefly depicted in Scheme 5.

4. Experimental

All reagents, except for Mn(acac)3 and Mn(OAc)3·2H2O, were commercially available and used without further purification. Tris(2,4-pentanedionato)manganese(III), Mn(acac)3, was prepared by reaction of 2,4-pentanedione, Hacac, with potassium permanganate, KMnO4 [29]. Manganese(III) acetate dihydrate, Mn(OAc)3·2H2O, was prepared according to our modified method [16]. Flash column chromatography was performed on silica gel 60N (40–50 μm), which was purchased from Kanto Chemical Co., Inc., (Tokyo, Japan) and preparative thin layer chromatography (TLC) on Wakogel B-5F from Wako Pure Chemical Ind., Ltd. (Osaka, Japan). The solvents were commercially available first grade and used as received. Melting points were obtained using a Yanagimoto micromelting point apparatus and are uncorrected. The NMR spectra were recorded using a JNM ECX 500 spectrometer at 500 MHz for 1H and at 125 MHz for 13C (Kumamoto, Japan), with tetramethylsilane as the internal standard. The chemical shifts are reported as δ values (ppm). The IR spectra were measured in CHCl3 using a Shimadzu 8400 FT-IR spectrometer and expressed in cm−1 (Kumamoto, Japan). The high-resolution mass spectra and the elemental analysis were performed at the Instrumental Analysis Center, Kumamoto University, Kumamoto, Japan. The X-ray analysis was performed using a SuperNova A diffractometer with a Cu micro-focus source and the final obtained structure was of very high quality and automatically solved by the AutoChem module.

4-Acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one (4) [2,3]

Mn(acac)3 (351.1 mg) was stirred in a mixture of AcOH (22.5 mL) and TFE (2.5 mL) at room temperature in air for 12 h. The solvent was removed in vacuo and the residue was triturated with 2M hydrochloric acid. The obtained aqueous acidic mixture was extracted with CHCl3 (20 mL × 3). The combined organic extracts were washed with aqueous NaHCO3 solution, water, dried (MgSO4), and then concentrated dryness. The obtained products were separated by column chromatography eluted by EtOAc–hexane (1:1 v/v), affording 4 (74.1 mg; 44%) (Table 1, Entry 6).
In contrast, Hacac (308.6 mg) and Mn(OAc)3·2H2O (407.1 mg) were added in a mixture of AcOH (13.5 mL) and TFE (1.5 mL), and the mixture was then stirred at room temperature under a dried air stream for 12 h. The work-up was performed by the procedure described above, giving 4 (159.4 mg; 61%) (Table 1, Entry 15).
Coloress prisms (from CHCl3); mp 116.0–116.3 °C; Rf = 0.57 (EtOAc-hexane, 1:1 v/v); IR (CHCl3) ν 1712, 1674 (C=O); 1H-NMR (500 MHz, CDCl3) δ 4.21 (1H, s, OH), 2.63 (3H, s, Ac), 2.43 (3H, s, CH3), 1.62 (3H, s, CH3); 1H-NMR (500 MHz, DMSO-d6) δ 8.06 (1H, s, OH), 2.56 (3H, s, Ac), 2.28 (3H, s, CH3), 1.39 (3H, s, CH3); 13C-NMR (125 MHz, DMSO-d6) δ 197.4 (C-3), 195.7 (Ac), 193.3 (C-5), 113.1 (C-4), 107.1 (C-2), 30.0 (Ac), 22.1 (CH3), 18.8 (CH3); 13C-NMR (125 MHz, CDCl3) δ 196.9 (C-3), 195.9 (Ac), 194.0 (C-5), 113.0 (C-4), 105.7 (C-2), 29.7 (Ac), 21.7 (CH3), 18.5 (CH3); Found: C, 56.38; H, 5.95%. Calcd for C8H10O4: C, 56.46; H, 5.92%.
X-Ray Crystallographic Data: empirical formula C8H10O4; formula weight 170.16; colorless prisms; space group P21/c; cell lengths a = 8.13551(9), b = 12.91881(9), c = 8.38084(9) Å; cell angles α = 90.00°, β = 114.5940(13)°, γ = 90.00°; cell volume 800.926 Å3; formula units per cell Z = 4, Z’ = 0; density ρ= 1.411 g/cm3; absorption coefficient μ = 0.970; radiation (CuKα) λ= 1.54184; R = 0.0342; Rw = 0.0860; GOF = 1.053. (CCDC 1501028 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html (or from the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; Fax: +44 1223 336033; E-mail: [email protected])).

4-Acetyl-2,5-dimethyl-3-oxo-2,3-dihydrofuran-2-yl Acetate (5) [2]

A mixture of the furanone 4 (84.8 mg) and acetyl chloride was heated under reflux for 3 h, then concentrated to dryness, giving the acetate 5 (74.3 mg; 70%) (89% yield based on the 1H-NMR spectrum). The acetate 5 was easily hydrolyzed during the work-up, yielding a mixture of the furanone 4.
Pale yellow liquid; Rf = 0.36 (EtOAc-hexane, 2:8 v/v); IR (CHCl3) ν 1768, 1723, 1687 (C=O); 1H-NMR (500 MHz, CDCl3) δ 2.58 (3H, s, Ac), 2.45 (3H, s, CH3), 2.13 (3H, s, OAc), 1.58 (3H, s, CH3); 13C-NMR (125 MHz, CDCl3) δ 195.0 (C-3), 193.8 (Ac), 193.2 (C-5), 114.3 (C-4), 102.1 (C-2), 29.8 (Ac), 21.0 (CH3), 20.2 (OAc), 17.6 (CH3); FAB HRMS (acetone/NBA): calcd for C10H12O5 212.0688 (M); found 212.0685.

4-Acetyl-2-methoxy-2,5-dimethylfuran-3(2H)-one (6)

The franone 4 (744.4 mg) and p-toluenesulfonic acid (84.9 mg) were heated under reflux in MeOH (20 mL) for 8.5 h and aqueous NaHCO3 solution (20 mL) was then added to the mixture. The aqueous solution was extracted with CHCl3 (20 mL × 3) and the combined organic extracts were dried (MgSO4) and then concentrated dryness, quantitatively giving the liquid methoxy-acetal 6 (802.6 mg; quant).
Pale yellow liquid; Rf = 0.52 (EtOAc-hexane, 2:8 v/v); IR (CHCl3) ν 1712, 1674 (C=O); 1H-NMR (500 MHz, CDCl3) δ 3.28 (3H, s, OCH3), 2.68 (3H, s, Ac), 2.46 (3H, s, CH3), 1.55 (3H, s, CH3); 13C-NMR (125 MHz, CDCl3) δ 196.3 (C-3), 196.1 (Ac), 193.3 (C-5), 114.7 (C-4), 109.0 (C-2), 52.3 (OMe), 29.8 (Ac), 20.8 (CH3), 18.1 (CH3); FAB HRMS (acetone/NBA): calcd for C9H13O4 185.0814 (M + H); found 185.0804.

5. Conclusions

It was confirmed that the product obtained by the oxidation of Mn(acac)3 or Hacac with Mn(OAc)3 in AcOH was not 3-acetyl-4-hydroxyhex-3-ene-2,5-dione (3), but 4-acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one (4), of which the best yield was accomplished by the reaction at room temperature under a dried air stream in AcOH-TFE. In addition, we proposed the mechanism for the formation of 4. Recently, Wu et al. also reported the isolation of the furanone 4 by the extremely complicated polyoxometalates-catalyzed oxidation of Hacac with hydrogen peroxide [30]. However, they did not mention the formation mechanism. The present method is superior in view of the synthesis of 4 than Wu’s because of a very easy handling procedure using commercially-available simple materials [31] under mild conditions, such as room temperature in air, in addition to a synthetically acceptable yield, and the reaction using various 1,3-dicarbonyl derivatives are currently underway in our laboratory. A similar compound, ethyl 2-(2-hydroxy-3-oxo-5-phenyl-2,3-dihydrofuran-2-yl)acetate, is also known [32], which was prepared by condensation of ethyl acetate with diethyl oxalate and acetophenone.

Supplementary Materials

The followings are available online at https://www.mdpi.com/1422-8599/2016/4/M913, 1H-NMR, 13C-NMR, and IR spectra, ORTEP drawing and cif of 4; 1H-NMR and 13C-NMR spectra of 5; 1H-NMR, 13C-NMR, DEPT, IR, and FAB MS spectra of 6.
Supplementary File 1Supplementary File 2Supplementary File 3Supplementary File 4

Acknowledgments

This research was supported by a Grant-in-Aid for Scientific Research (C), No. 25410049, from the Japan Society for the Promotion of Science. We also acknowledge Nissan Chemical Industries, Ltd., and Astellas Foundation for Research on Metabolic Disorders for their financial support.

Author Contributions

H.N. conceived and designed the experiments; C.A. and S.K. performed the experiments; H.N. analyzed the data, contributed reagents/materials/analysis tools, and wrote the manuscript. All authors read and approved the final manuscript.

Conflicts of Interest

The authors declare no conflict of interest.

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Molbank 2016 m913 sch001 550
Scheme 1. Synthesis of Dihydrofurans and 1,2-Dioxan-3-ols Using Mn(III) Complexes.
Scheme 1. Synthesis of Dihydrofurans and 1,2-Dioxan-3-ols Using Mn(III) Complexes.
Molbank 2016 m913 sch001
Molbank 2016 m913 sch002 550
Scheme 2. Tautomerism of the by-product 3.
Scheme 2. Tautomerism of the by-product 3.
Molbank 2016 m913 sch002
Molbank 2016 m913 sch003 550
Scheme 3. Production of the furanone 4.
Scheme 3. Production of the furanone 4.
Molbank 2016 m913 sch003
Molbank 2016 m913 sch004 550
Scheme 4. Conversion of the furanone 4.
Scheme 4. Conversion of the furanone 4.
Molbank 2016 m913 sch004
Molbank 2016 m913 sch005 550
Scheme 5. Proposed mechanism for the formation of the furanone 4.
Scheme 5. Proposed mechanism for the formation of the furanone 4.
Molbank 2016 m913 sch005
Table
Table 1. Reaction of Mn(acac)3 1 and 2,4-Pentanedione (Hacac) with Mn(OAc)3 in AcOH 2.
Table 1. Reaction of Mn(acac)3 1 and 2,4-Pentanedione (Hacac) with Mn(OAc)3 in AcOH 2.
EntryConditionsAdditiveTime/h4/Yield/% 3
1Mn(acac)3argon 1214
2 air 1235
3 dried air stream 1235
4 O2 (1 atm) 1239
5 O2 (5 atm)MS4A624
6 airCF3CH2OH 41244
7Mn(OAc)3/Hacacargon 1815
8 air 1829
9 airMS4A1814
10 airHCO2H 535
11 airNaOAc 61221
12 dried air stream 1252
13 O2 (1 atm)CF3CH2OH 41249
14 airCF3CH2OH 41258
15 dry-air streamCF3CH2OH 41261
1 Mn(acac)3 (1.0 mmol) was used in AcOH (25 mL); 2 Hacac (3.0 mmol) and Mn(OAc)3·2H2O (1.5 mmol) were used in AcOH (15 mL); 3 Entries 1–5: Isolated yield based on Mn(acac)3. Entries 6–10: Isolated yield based on Hacac; 4 AcOH:CF3CH2OH = 9:1 v/v; 5 AcOH:HCO2H = 9:1 v/v; 6 NaOAc (6.0 mmol) was added.

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Akazaki, C.; Kawabata, S.; Nishino, H. 4-Acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one. Molbank 2016, 2016, M913. https://doi.org/10.3390/M913

AMA Style

Akazaki C, Kawabata S, Nishino H. 4-Acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one. Molbank. 2016; 2016(4):M913. https://doi.org/10.3390/M913

Chicago/Turabian Style

Akazaki, Chiaki, Shun Kawabata, and Hiroshi Nishino. 2016. "4-Acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one" Molbank 2016, no. 4: M913. https://doi.org/10.3390/M913

APA Style

Akazaki, C., Kawabata, S., & Nishino, H. (2016). 4-Acetyl-2-hydroxy-2,5-dimethylfuran-3(2H)-one. Molbank, 2016(4), M913. https://doi.org/10.3390/M913

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