α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside]
Abstract
:1. Introduction
2. Results
3. Experimental Section
3.1. General Experimental Procedures
3.2. Mangrove Plant Sample Collection
3.3. Isolation and Purification of the Endophytic Mycobacterium Strain
3.4. Fermentation
3.4.1. Extraction and Purification
3.4.2. α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside] (1)
3.4.3. Acid Hydrolysis of Compound 1
3.5. Bioassay Reagents
3.5.1. Compound Preparation for Bioassay
3.5.2. Cell Culture
3.5.3. In Vitro Viability Test for Trypanosome Parasites
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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# | δc mult | δH mult (J Hz) | 1H-1H COSY | HMBC | TOCSY |
---|---|---|---|---|---|
1 NH | 10.9, d (2.9) | 2 | C-2, C-3, C-3a, C-7a | ||
2 | 124.2, CH | 7.22, d (2.9) | 1NH | C-3, C-3a, C-7a | 1NH |
3 | 109.1, C | ||||
3a | 127.2, C | ||||
4 | 118.3, CH | 7.59, d (8.1) | 5 | C-3, C-3a, C-6, C-7a | 5, 6,7 |
5 | 118.4, CH | 6.97, m | 4 | C-3a, C-7 | 4, 6, 7 |
6 | 120.9, CH | 7.06, m | 7 | C-4, C-5, C-7a | 4, 5, 7 |
7 | 111.4, CH | 7.35, m | 6 | C-3a, C-4, C-5 | 4, 5, 6 |
7a | 136.3, C | ||||
8 | 26.9, CH2 | 3.02, dd (15.3, 8.7) 3.32, dd (15.1, 4.4) | 8, 9 8, 9 | C-2, C-3, C-3a, C-9, C-10 | 9, 2 |
9 | 54.5, CH | 3.55, m | 8 | 8 | |
9 NH2 | 3.59, dd (2.3, 4.3) | ||||
10 | 170.8, C | ||||
1′ | 62.2, CH2 | 3.41, d (3.1) | C-2′, C-3′ | 3′, 4′, 6′ | |
2′ | 104.0, C | ||||
3′ | 77.2, CH | 3.89, d (8.1) | C-1′, C-4′, C-6′ | 4′, 5′ | |
4′ | 74.3, CH | 3.79, t (7.7) | 5′ | C-1′, C-5′, C-6′ | 3′, 5′ |
5′ | 82.5, CH | 3.57, dt (7.7, 2.2) | 4′ | 3′, 4′ | |
6′ | 62.1, CH2 | 3.41, d (2.3) | C-10 | 1′, 3′, 4′ | |
1′′ | 91.8, CH | 5.19, d (4.1) | 2′′ | C-5′′, C-2′ | 5′′, 2′′, |
2′′ | 71.7, CH | 3.20, dd (9.7, 3.9) | 1′′ | 5′′, 3′′, 4′′, 1′′ | |
3′′ | 72.8, CH | 3.49, t (9.7) | 4′′ | C-2′′, C-4′′ | 5′′, 2′′, 4′′, 1′′ |
4′′ | 69.9, CH | 3.14, t (9.5) | 3′′, 5′′ | C-5′′, C-6′′ | 5′′, 6′′, 2′′, 1′′ |
5′′ | 72.9, CH | 3.65, ddd (9.7, 4.7, 2.4) | 4′′ | 1′′, 2′′, 3′′, 4′′ | |
6′′ | 60.5, CH2 | 3.52, dd (10, 4.8,) 3.50, dd (10, 2.6) | 5′′, 4′′ |
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Kyeremeh, K.; Kwain, S.; Tetevi, G.M.; Camas, A.S.; Camas, M.; Dofuor, A.K.; Deng, H.; Jaspars, M. α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside]. Molbank 2019, 2019, M1066. https://doi.org/10.3390/M1066
Kyeremeh K, Kwain S, Tetevi GM, Camas AS, Camas M, Dofuor AK, Deng H, Jaspars M. α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside]. Molbank. 2019; 2019(2):M1066. https://doi.org/10.3390/M1066
Chicago/Turabian StyleKyeremeh, Kwaku, Samuel Kwain, Gilbert Mawuli Tetevi, Anil Sazak Camas, Mustafa Camas, Aboagye Kwarteng Dofuor, Hai Deng, and Marcel Jaspars. 2019. "α-d-Glucopyranosyl-(1→2)-[6-O-(l-tryptophanyl)-β-d-fructofuranoside]" Molbank 2019, no. 2: M1066. https://doi.org/10.3390/M1066